Transcriptome analysis in LRRK2 and idiopathic Parkinson's disease at different glucose levels

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  • dc.contributor.author Fernández-Santiago, Ruben
  • dc.contributor.author Esteve-Codina, Anna
  • dc.contributor.author Fernández, Manel
  • dc.contributor.author Valldeoriola, Francesc
  • dc.contributor.author Sanchez-Gómez, Almudena
  • dc.contributor.author Muñoz, Esteban
  • dc.contributor.author Compta, Yaroslau
  • dc.contributor.author Tolosa, Eduard
  • dc.contributor.author Ezquerra, Mario
  • dc.contributor.author Martí, Maria José
  • dc.date.accessioned 2022-03-28T06:30:54Z
  • dc.date.available 2022-03-28T06:30:54Z
  • dc.date.issued 2021
  • dc.description.abstract Type-2 diabetes (T2D) and glucose metabolic imbalances have been linked to neurodegenerative diseases, including Parkinson's disease (PD). To detect potential effects of different glucose levels on gene expression, by RNA-seq we analyzed the transcriptome of dermal fibroblasts from idiopathic PD (iPD) patients, LRRK2-associated PD (L2PD) patients, and healthy controls (total n = 21 cell lines), which were cultured at two different glucose concentrations (25 and 5 mM glucose). In PD patients we identified differentially expressed genes (DEGs) that were related to biological processes mainly involving the plasmatic cell membrane, the extracellular matrix, and also neuronal functions. Such pathway deregulation was largely similar in iPD or L2PD fibroblasts. Overall, the gene expression changes detected in this study were associated with PD independently of glucose concentration.
  • dc.description.sponsorship This work was supported by CIBERNED / Instituto de Salud Carlos III (ISCIII) (grant PIE14/00061) (to M.-J.M.), and the Fondo de Investigaciones Sanitarias from ISCIII (grant PIE20/00259) (to M.E.). R.F.-S. was supported by a Jóvenes Investigadores (JIN) grant of the Spanish Ministry of Economy and Competitiveness (MINECO) and the Agencia Estatal de Investigación (AEI) (AEI/FEDER/UE) (grant #SAF2015-73508-JIN), and a Miguel Servet grant from the Instituto de Salud Carlos III (grant #CP19/00048). A.E-C. was funded by ISCIII /MINECO (PT17/0009/0019) and co-funded by FEDER. M.F. was funded through a María de Maeztu grant (#MDM-2017-0729). IDIBAPS receives funding from the CERCA Program from the Generalitat de Catalunya and the FEDER Program from the European Union.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Fernández-Santiago R, Esteve-Codina A, Fernández M, Valldeoriola F, Sanchez-Gómez A, Muñoz E. Transcriptome analysis in LRRK2 and idiopathic Parkinson's disease at different glucose levels. NPJ Parkinsons Dis. 2021 Dec 1;7(1):109. DOI: 10.1038/s41531-021-00255-x
  • dc.identifier.doi http://dx.doi.org/10.1038/s41531-021-00255-x
  • dc.identifier.issn 2373-8057
  • dc.identifier.uri http://hdl.handle.net/10230/52778
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof NPJ Parkinsons Dis. 2021 Dec 1;7(1):109
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-73508-JIN
  • dc.rights © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Gene expression profiling
  • dc.subject.keyword Parkinson's disease
  • dc.title Transcriptome analysis in LRRK2 and idiopathic Parkinson's disease at different glucose levels
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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