Maternal separation increases alcohol-drinking behaviour and reduces endocannabinoid levels in the mouse striatum and prefrontal cortex

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• dc.contributor.author Portero Tresserra, Marta
• dc.contributor.author Gracia Rubio, Irene, 1986-
• dc.contributor.author Cantacorps Centellas, Lídia, 1991-
• dc.contributor.author Pozo Mendoza, Óscar J., 1975-
• dc.contributor.author Gomez-Gomez, Àlex
• dc.contributor.author Pastor, Antonio
• dc.contributor.author López Arnau, Raúl
• dc.contributor.author Torre Fornell, Rafael de la
• dc.contributor.author Valverde Granados, Olga
• dc.date.accessioned 2018-11-07T08:37:09Z
• dc.date.issued 2018
• dc.description.abstract Childhood adversity is associated with an increased risk of mood, anxiety and substance use disorders. Maternal separation is a reliable rodent model of early life adversity that leads to depression-like symptoms, which may increase the vulnerability to alcohol consumption during adolescence. However, the specific alterations in the pattern of alcohol consumption induced by maternal separation and the underlying molecular mechanisms are still unclear. The purpose of this study is to evaluate the long-term effects of maternal separation with early weaning (MSEW) on emotional and social behaviour, alcohol rewarding properties, and alcohol consumption, abstinence and relapse in adolescent male C57BL/6 mice. In addition, endocannabinoid and monoamine levels were analysed in discrete brain areas. Results showed that MSEW mice presented emotional alterations related to depressive-like behaviour and modified endocannabinoid levels in the striatum and the prefrontal cortex. MSEW mice also showed impairments in alcohol-induced conditioned place preference and higher alcohol intake in a model of binge drinking. Moreover, MSEW animals displayed a higher propensity to relapse in the two-bottle choice paradigm following a period of alcohol abstinence associated with reduced monoamine levels in the striatum. Such results indicate that exposure to early life stress increased the vulnerability to alcohol binge-drinking during adolescence, which may be partially explained by decreased sensitivity to alcohol rewarding properties and the ability to potentiate alcohol intake following a period of abstinence.
• dc.description.sponsorship This study was supported by MINECO (SAF2016-75966-R, FEDER),Plan Nacional sobre Drogas (2014/020), ISCIII and FEDER (CPII16/00027), UE Medbioinformatic project (grant number 634143) and grants from DIUE, Generalitat de Catalunya (2014SGR 680). RL-A’sposition was funded by an institutional program of the University of Barcelona in collaboration with the “Obra Social de la Fundació Bancària La Caixa”.
• dc.format.mimetype application/pdf
• dc.identifier.citation Portero-Tresserra M, Gracia-Rubio I, Cantacorps L, Pozo OJ, Gómez-Gómez A, Pastor A et al. Maternal separation increases alcohol-drinking behaviour and reduces endocannabinoid levels in the mouse striatum and prefrontal cortex. Eur Neuropsychopharmacol. 2018 Apr;28(4):499-512. DOI: 10.1016/j.euroneuro.2018.02.003. Epub 2018 Feb 23
• dc.identifier.doi http://dx.doi.org/10.1016/j.euroneuro.2018.02.003
• dc.identifier.issn 0924-977X
• dc.identifier.uri http://hdl.handle.net/10230/35712
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof European Neuropsychopharmacology. 2018 Apr;28(4):499-512
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634143
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-75966-R
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.euroneuro.2018.02.003
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Adolescence
• dc.subject.keyword Alcohol
• dc.subject.keyword Endocannabinoids
• dc.subject.keyword Maternal separation
• dc.subject.keyword Monoamines
• dc.subject.keyword Striatum
• dc.subject.keyword Adolescents -- Consum d'alcohol
• dc.subject.keyword Adolescents -- Consum de tabac
• dc.title Maternal separation increases alcohol-drinking behaviour and reduces endocannabinoid levels in the mouse striatum and prefrontal cortex
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion