Genetic affinities of an eradicated European Plasmodium falciparum strain

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• dc.contributor.author de Dios, Toni
• dc.contributor.author van Dorp, Lucy
• dc.contributor.author Gelabert Xirinachs, Pere, 1991-
• dc.contributor.author Carøe, Christian
• dc.contributor.author Sandoval Velasco, Marcela
• dc.contributor.author Fregel, Rosa
• dc.contributor.author Escosa, Raül
• dc.contributor.author Aranda, Carles
• dc.contributor.author Huijben, Silvie
• dc.contributor.author Balloux, François
• dc.contributor.author Gilbert, M Thomas
• dc.contributor.author Lalueza Fox, Carles, 1965-
• dc.date.accessioned 2020-07-07T06:31:43Z
• dc.date.available 2020-07-07T06:31:43Z
• dc.date.issued 2019
• dc.description.abstract Malaria was present in most of Europe until the second half of the 20th century, when it was eradicated through a combination of increased surveillance and mosquito control strategies, together with cross-border and political collaboration. Despite the severe burden of malaria on human populations, it remains contentious how the disease arrived and spread in Europe. Here, we report a partial Plasmodium falciparum nuclear genome derived from a set of antique medical slides stained with the blood of malaria-infected patients from Spain's Ebro Delta, dating to the 1940s. Our analyses of the genome of this now eradicated European P. falciparum strain confirms stronger phylogeographical affinity to present-day strains in circulation in central south Asia, rather than to those in Africa. This points to a longitudinal, rather than a latitudinal, spread of malaria into Europe. In addition, this genome displays two derived alleles in the pfmrp1 gene that have been associated with drug resistance. Whilst this could represent standing variation in the ancestral P. falciparum population, these mutations may also have arisen due to the selective pressure of quinine treatment, which was an anti-malarial drug already in use by the time the sample we sequenced was mounted on a slide.
• dc.format.mimetype application/pdf
• dc.identifier.citation de-Dios T, van Dorp L, Gelabert P, Carøe C, Sandoval-Velasco M, Fregel R, Escosa R, Aranda C, Huijben S, Balloux F, Gilbert MTP, Lalueza-Fox C. Genetic affinities of an eradicated European Plasmodium falciparum strain. Microb Genom. 2019; 5(9):e000289. DOI: 10.1099/mgen.0.000289
• dc.identifier.doi http://dx.doi.org/10.1099/mgen.0.000289
• dc.identifier.issn 2057-5858
• dc.identifier.uri http://hdl.handle.net/10230/45081
• dc.language.iso eng
• dc.publisher Microbiology Society
• dc.relation.ispartof Microb Genom. 2019; 5(9):e000289
• dc.rights © 2019 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Plasmodium falciparum
• dc.subject.keyword Ancient genomics
• dc.subject.keyword Drug resistance
• dc.subject.keyword Malaria
• dc.title Genetic affinities of an eradicated European Plasmodium falciparum strain
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion