Occupational exposure to radiofrequency electromagnetic fields and brain tumor risk: Application of the INTEROCC job-exposure matrix

Turuban, Maxime; Kromhout, Hans; Vila, Javier; Vallbona-Vistós, Miquel; De Vocht, Frank; Baldi, Isabelle; Richardson, Lesley; Benke, Geza; Krewski, Daniel; Parent, Marie-Elise; Sadetzki, Siegal; Schlehofer, Brigitte; Schüz, Joachim; Siemiatycki, Jack; van Tongeren, Martie; Woodward, Alistair; Cardis, Elisabeth; Turner, Michelle C.

Occupational exposure to radiofrequency electromagnetic fields and brain tumor risk: Application of the INTEROCC job-exposure matrix

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dc.contributor.author Turuban, Maxime
dc.contributor.author Kromhout, Hans
dc.contributor.author Vila, Javier
dc.contributor.author Vallbona-Vistós, Miquel
dc.contributor.author De Vocht, Frank
dc.contributor.author Baldi, Isabelle
dc.contributor.author Richardson, Lesley
dc.contributor.author Benke, Geza
dc.contributor.author Krewski, Daniel
dc.contributor.author Parent, Marie-Elise
dc.contributor.author Sadetzki, Siegal
dc.contributor.author Schlehofer, Brigitte
dc.contributor.author Schüz, Joachim
dc.contributor.author Siemiatycki, Jack
dc.contributor.author van Tongeren, Martie
dc.contributor.author Woodward, Alistair
dc.contributor.author Cardis, Elisabeth
dc.contributor.author Turner, Michelle C.
dc.date.accessioned 2024-11-22T11:37:13Z
dc.date.available 2024-11-22T11:37:13Z
dc.date.issued 2024
dc.description Data de publicació electrònica: 20-09-2024
dc.description.abstract Radiofrequency electromagnetic fields (RF-EMF, 100 kHz to 300 GHz) are classified by IARC as possibly carcinogenic to humans (Group 2B). This study evaluates the potential association between occupational RF-EMF exposure and brain tumor risk, utilizing for the first time, a RF-EMF job-exposure matrix (RF-JEM) developed in the multi-country INTEROCC case-control study. Cumulative and time-weighted average (TWA) occupational RF-EMF exposures were estimated for study participants based on lifetime job histories linked to the RF-JEM using three different methods: (1) by considering RF-EMF intensity among all exposed jobs, (2) by considering RF-EMF intensity among jobs with an exposure prevalence ≥ the median exposure prevalence of all exposed jobs, and (3) by considering RF-EMF intensity of jobs of participants who reported RF-EMF source use. Stratified conditional logistic regression models were used, considering various lag periods and exposure time windows defined a priori. Generally, no clear associations were found for glioma or meningioma risk. However, some statistically significant positive associations were observed including in the highest exposure categories for glioma for cumulative and TWA exposure in the 1- to 4-year time window for electric fields (E) in the first JEM application method (odds ratios [ORs] = 1.36, 95% confidence interval [95% CI] 1.08, 1.72 and 1.27, 95% CI 1.01, 1.59, respectively), as well as for meningioma for cumulative exposure in the 5- to 9-year time window for electric fields (E) in the third JEM application method (OR = 2.30, 95% CI 1.11, 4.78). We did not identify convincing associations between occupational RF-EMF exposure and risk of glioma or meningioma.
dc.format.mimetype application/pdf
dc.identifier.citation Turuban M, Kromhout H, Vila J, Vallbona-Vistós M, De Vocht F, Baldi I, et al. Occupational exposure to radiofrequency electromagnetic fields and brain tumor risk: Application of the INTEROCC job-exposure matrix. Int J Cancer. 2024 Sep 20. DOI: 10.1002/ijc.35182
dc.identifier.doi http://dx.doi.org/10.1002/ijc.35182
dc.identifier.issn 0020-7136
dc.identifier.uri http://hdl.handle.net/10230/68791
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Int J Cancer. 2024 Sep 20
dc.rights © 2024 The Author(s). International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword INTEROCC
dc.subject.keyword Brain tumors
dc.subject.keyword Job‐exposure matrix
dc.subject.keyword Occupational exposure
dc.subject.keyword Radiofrequency electromagnetic fields
dc.title Occupational exposure to radiofrequency electromagnetic fields and brain tumor risk: Application of the INTEROCC job-exposure matrix
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Departament de Medicina i Ciències de la Vida)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)