Latent childhood exposure to mixtures of metals and neurodevelopmental outcomes in 4–5-year-old children living in Spain

Notario Barandiaran, Leyre; Díaz-Coto, Susana; Jiménez-Redondo, Nuria; Guxens Junyent, Mònica; Vrijheid, Martine; Andiarena, Ainara; Irizar, Amaia; Riaño-Galán, Isolina; Fernández-Somoano, Ana; Llop, Sabrina; Lozano, Manuel; Karagas, Margaret R.; Meharg, Andrew A.; Carey, Manus; Meharg, Caroline; Ralphs, Kathryn; McCreanor, Coalain; Vioque, Jesus; Martinez-Camblor, Pablo; Signes-Pastor, Antonio J.

Latent childhood exposure to mixtures of metals and neurodevelopmental outcomes in 4–5-year-old children living in Spain

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dc.contributor.author Notario Barandiaran, Leyre
dc.contributor.author Díaz-Coto, Susana
dc.contributor.author Jiménez-Redondo, Nuria
dc.contributor.author Guxens Junyent, Mònica
dc.contributor.author Vrijheid, Martine
dc.contributor.author Andiarena, Ainara
dc.contributor.author Irizar, Amaia
dc.contributor.author Riaño-Galán, Isolina
dc.contributor.author Fernández-Somoano, Ana
dc.contributor.author Llop, Sabrina
dc.contributor.author Lozano, Manuel
dc.contributor.author Karagas, Margaret R.
dc.contributor.author Meharg, Andrew A.
dc.contributor.author Carey, Manus
dc.contributor.author Meharg, Caroline
dc.contributor.author Ralphs, Kathryn
dc.contributor.author McCreanor, Coalain
dc.contributor.author Vioque, Jesus
dc.contributor.author Martinez-Camblor, Pablo
dc.contributor.author Signes-Pastor, Antonio J.
dc.date.accessioned 2024-02-16T07:49:37Z
dc.date.available 2024-02-16T07:49:37Z
dc.date.issued 2023
dc.description Data de publicació electrònica: 2023-10-31
dc.description.abstract Neurodevelopmental disorders are increasing globally, and metal exposure may play a significant role as an environmental factor. This cross-sectional study aimed to identify metal mixture patterns and assess their impact on children’s neurodevelopment. Data from 962 children (aged 4–5 years) participating in the Spanish INMA cohort study were analysed. Urinary metal concentrations (cobalt (Co), copper (Cu), molybdenum (Mo), selenium (Se), lead (Pb), zinc (Zn), and arsenic speciation) were used as exposure biomarkers. Principal component analysis (PCA) revealed four latent exposure variables representing uncorrelated metal mixture patterns. Linear regression analyses examined the associations between these variables and children’s neuropsychological functions assessed through the McCarthy Scales of Children’s Abilities. The first latent exposure variable (Cu, Se, Pb, Zn) and the second (inorganic arsenic, monomethylarsonic acid) showed negative associations with verbal executive function (ß = − 1.88, 95% confidence interval (CI) = − 3.17 to − 0.59) and gross motor function (ß = − 1.41, 95% CI = − 2.36 to − 0.46), respectively. Conversely, the third variable (Mo, Co) and the fourth (arsenobetaine) exhibited positive associations with visual and verbal span functions (ß = 1.14, 95% CI = 0.16 to 2.12) and fine motor function (ß = 1.01, 95% CI = 0.11 to 1.92), respectively. This study suggests that even relatively low levels of metal latent exposures, notably inorganic arsenic and a mixture of metals including Pb, adversely affect children’s neuropsychological development function scores, while exposure to arsenobetaine and a mixture of Co and Mo has a positive impact.
dc.description.sponsorship Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was funded by CIDEGENT/2020/050; by grants from Instituto de Salud Carlos III: Red INMA G03/176; CB06/02/0041; PI041436; PI081151, PI11/01007, PI07/0314, PI04/2018, PI09/02311, PI13/02429, PI18/00909 co-funded by the European Regional Development Fund (FEDER), “A way to make Europe”/“Investing in your future”; Fundación Cajastur, and Universidad de Oviedo.; FIS-FEDER: 13/1944, 16/1288, 19/1338; ISGlobal acknowledges support from the grant CEX2018-000806-S funded by MCIN/AEI/https://doi.org/10.13039/501100011033, and support from the Generalitat de Catalunya through the CERCA Program; Miguel Servet-FSE: MS15/0025, MS20/0006, H2020-EU No 874583 (ATHLETE project), Generalitat Valenciana (CIAICO/2021/132, BEST/2020/059 and AICO 2020/285. Ministry of Universities (CAS21/00008, NextGenerationEU). Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430). We acknowledge support from the grant CEX2018-000806-S funded by MCIN/AEI/https://doi.org/10.13039/501100011033, and support from the Generalitat de Catalunya through the CERCA Program. Mònica Guxens is funded by a Miguel Servet II fellowship (CPII18/00018) awarded by the Spanish Institute of Health Carlos III.
dc.format.mimetype application/pdf
dc.identifier.citation Notario-Barandiaran L, Díaz-Coto S, Jimenez-Redondo N, Guxens M, Vrijheid M, Andiarena A, Irizar A, Riaño-Galan I, Fernández-Somoano A, Llop S, Lozano M, Karagas MR, Meharg A, Carey M, Meharg C, Ralphs K, McCreanor C, Vioque J, MartinezCamblor P, Signes-Pastor AJ. Latent childhood exposure to mixtures of metals and neurodevelopmental outcomes in 4–5-year-old children living in Spain. Expo Health. 2023. DOI: 10.1007/s12403-023-00610-8
dc.identifier.doi http://dx.doi.org/10.1007/s12403-023-00610-8
dc.identifier.issn 2451-9766
dc.identifier.uri http://hdl.handle.net/10230/59118
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Expo Health. 2023
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Mixture
dc.subject.keyword Heavy metals
dc.subject.keyword Children's environmental health
dc.subject.keyword Neurodevelopmental outcomes
dc.subject.keyword Biomarkers of exposure
dc.subject.keyword Neuropsychological functions
dc.title Latent childhood exposure to mixtures of metals and neurodevelopmental outcomes in 4–5-year-old children living in Spain
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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