Evolutionary and medical consequences of archaic introgression into modern human genomes
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- dc.contributor.author Dolgova, Olga
- dc.contributor.author Lao Grueso, Oscar, 1976-
- dc.date.accessioned 2019-11-19T07:55:52Z
- dc.date.available 2019-11-19T07:55:52Z
- dc.date.issued 2018
- dc.description.abstract The demographic history of anatomically modern humans (AMH) involves multiple migration events, population extinctions and genetic adaptations. As genome-wide data from complete genome sequencing becomes increasingly abundant and available even from extinct hominins, new insights of the evolutionary history of our species are discovered. It is currently known that AMH interbred with archaic hominins once they left the African continent. Current non-African human genomes carry fragments of archaic origin. This review focuses on the fitness consequences of archaic interbreeding in current human populations. We discuss new insights and challenges that researchers face when interpreting the potential impact of introgression on fitness and testing hypotheses about the role of selection within the context of health and disease.
- dc.description.sponsorship This work was supported by a BFU2015-68759-P (MINECO/FEDER) grant and the support of Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 937). O.L was also supported by a Ramón y Cajal grant from the Spanish Ministerio de Economia y Competitividad (MINECO) with reference RYC-2013-14797.
- dc.format.mimetype application/pdf
- dc.identifier.citation Dolgova O, Lao O. Evolutionary and medical consequences of archaic introgression into modern human genomes. Genes (Basel). 2018; 9(7):358. DOI 10.3390/genes9070358
- dc.identifier.doi http://dx.doi.org/10.3390/genes9070358
- dc.identifier.issn 2073-4425
- dc.identifier.uri http://hdl.handle.net/10230/42888
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Genes (Basel). 2018; 9(7):358
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-68759-P
- dc.rights © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Archaic introgression
- dc.subject.keyword Fitness
- dc.subject.keyword Natural selection
- dc.subject.keyword Neanderthal
- dc.subject.keyword Denisovan
- dc.subject.keyword Anatomically modern humans
- dc.title Evolutionary and medical consequences of archaic introgression into modern human genomes
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion