A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women

Storniolo, Carolina Emilia; Casillas, Rosario; Bulló, Mònica; Castañer, Olga; Ros, Emilio; Sáez, Guillermo; Toledo, Estefania; Estruch, Ramón; Ruiz-Gutiérrez, Valentina; Fitó Colomer, Montserrat; Martínez-González, Miguel Ángel, 1957-; Salas-Salvadó, Jordi; Mitjavila, María Teresa; Moreno, Juan José

A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women

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dc.contributor.author Storniolo, Carolina Emiliaca
dc.contributor.author Casillas, Rosarioca
dc.contributor.author Bulló, Mònicaca
dc.contributor.author Castañer, Olgaca
dc.contributor.author Ros, Emilioca
dc.contributor.author Sáez, Guillermoca
dc.contributor.author Toledo, Estefaniaca
dc.contributor.author Estruch, Ramónca
dc.contributor.author Ruiz-Gutiérrez, Valentinaca
dc.contributor.author Fitó Colomer, Montserratca
dc.contributor.author Martínez-González, Miguel Ángel, 1957-ca
dc.contributor.author Salas-Salvadó, Jordica
dc.contributor.author Mitjavila, María Teresaca
dc.contributor.author Moreno, Juan Joséca
dc.date.accessioned 2017-06-26T10:09:30Z
dc.date.issued 2017
dc.description.abstract PURPOSE: Serum nitric oxide (NO) reduction and increased endothelin-1 (ET-1) play a pivotal role in endothelial dysfunction and hypertension. Considering that traditional Mediterranean diet (TMD) reduces blood pressure (BP), the aim of this study was to analyze whether TMD induced changes on endothelial physiology elements such as NO, ET-1 and ET-1 receptors which are involved in BP control. METHODS: Non-smoking women with moderate hypertension were submitted for 1 year to interventions promoting adherence to the TMD, one supplemented with extra virgin olive oil (EVOO) and the other with nuts versus a control low-fat diet (30 participants/group). BP, NO, ET-1 and related gene expression as well as oxidative stress biomarkers were measured. RESULTS: Serum NO and systolic BP (SBP) or diastolic BP (DBP) were negatively associated at baseline, as well as between NO and ET-1. Our findings also showed a DBP reduction with both interventions. A negative correlation was observed between changes in NO metabolites concentration and SBP or DBP after the intervention with TMD + EVOO (p = 0.033 and p = 0.044, respectively). SBP reduction was related to an impairment of serum ET-1 concentrations after the intervention with TMD + nuts (p = 0.008). We also observed changes in eNOS, caveolin 2 and ET-1 receptors gene expression which are related to NO metabolites levels and BP. CONCLUSIONS: The changes in NO and ET-1 as well as ET-1 receptors gene expression explain, at least partially, the effect of EVOO or nuts on lowering BP among hypertensive women..
dc.description.sponsorship This study was supported by the Spanish Ministry of Health (FIS PI10/0082, G03/140, RD06/0045), Fondo Europeo de Desarrollo Regional, the Spanish Ministry of Science (BFU2007-61727/BFI) and the Generalitat de Catalunya (2009SGR00438)
dc.format.mimetype application/pdfca
dc.identifier.citation Storniolo CE, Casillas R, Bulló M, Castañer O, Ros E, Sáez GT et al. A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women. Eur J Nutr. 2017 Feb; 56(1): 89-97. DOI: 10.1007/s00394-015-1060-5
dc.identifier.doi http://dx.doi.org/10.1007/s00394-015-1060-5
dc.identifier.issn 1436-6207
dc.identifier.uri http://hdl.handle.net/10230/32464
dc.language.iso eng
dc.publisher Springerca
dc.relation.ispartof European Journal of Nutrition. 2017 Feb;56(1):89-97
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/BFU2007-61727
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.other Dieta -- Mediterrània, Regió de la
dc.subject.other Oli d'oliva -- Ús terapèutic
dc.subject.other Fruita -- Ús terapèutic
dc.subject.other Pressió sanguínia
dc.subject.other Hipertensió
dc.title A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive womenca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/acceptedVersion

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