Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?

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  • dc.contributor.author Baeza, Immaculada
  • dc.contributor.author Serna, Elena de la
  • dc.contributor.author Mezquida, Gisela
  • dc.contributor.author Cuesta, Manuel J.
  • dc.contributor.author Vieta, Eduard
  • dc.contributor.author Amoretti, Silvia
  • dc.contributor.author Lobo, Antonio
  • dc.contributor.author González-Pinto, Ana
  • dc.contributor.author Díaz-Caneja, Covadonga M.
  • dc.contributor.author Corripio, Iluminada
  • dc.contributor.author Valli, Isabel
  • dc.contributor.author Puig, Olga
  • dc.contributor.author Mané Santacana, Anna
  • dc.contributor.author Bioque, Miquel
  • dc.contributor.author Ayora, Miriam
  • dc.contributor.author Bernardo, Miquel
  • dc.contributor.author Castro-Fornieles, Josefina
  • dc.contributor.author PEPs Group
  • dc.date.accessioned 2023-09-15T06:19:11Z
  • dc.date.available 2023-09-15T06:19:11Z
  • dc.date.issued 2024
  • dc.description.abstract To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on the duration of untreated psychosis (DUP) and prodromal symptoms in a sample of patients with a first episode of psychosis. 331 patients with a first episode of psychosis (7-35 years old) were recruited and 174 (52.6%) diagnosed with SSD or BD at one-year follow-up through a multicenter longitudinal study. The Symptom Onset in Schizophrenia (SOS) inventory, the Positive and Negative Syndrome Scale and the structured clinical interviews for DSM-IV diagnoses were administered. Generalized linear models compared the main effects and group interaction. 273 AOP (25.2 ± 5.1 years; 66.5% male) and 58 EOP patients (15.5 ± 1.8 years; 70.7% male) were included. EOP patients had significantly more prodromal symptoms with a higher frequency of trouble with thinking, avolition and hallucinations than AOP patients, and significantly different median DUP (91 [33-177] vs. 58 [21-140] days; Z = - 2.006, p = 0.045). This was also significantly longer in SSD vs. BD patients (90 [31-155] vs. 30 [7-66] days; Z = - 2.916, p = 0.004) who, moreover had different profiles of prodromal symptoms. When assessing the interaction between age at onset (EOP/AOP) and type of diagnosis (SSD/BD), avolition was significantly higher (Wald statistic = 3.945; p = 0.047), in AOP patients with SSD compared to AOP BD patients (p = 0.004). Awareness of differences in length of DUP and prodromal symptoms in EOP vs. AOP and SSD vs. BD patients could help improve the early detection of psychosis among minors.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Baeza I, de la Serna E, Mezquida G, Cuesta MJ, Vieta E, Amoretti S, et al. Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?. Eur Child Adolesc Psychiatry. 2024 Mar;33(3):799-810. DOI: 10.1007/s00787-023-02196-7
  • dc.identifier.doi http://dx.doi.org/10.1007/s00787-023-02196-7
  • dc.identifier.issn 1018-8827
  • dc.identifier.uri http://hdl.handle.net/10230/57865
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Eur Child Adolesc Psychiatry. 2023 Apr 7
  • dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Adult onset
  • dc.subject.keyword Children and adolescents
  • dc.subject.keyword Prodromal symptoms
  • dc.subject.keyword Prodrome
  • dc.subject.keyword Schizophrenia
  • dc.subject.keyword Bipolar disorder
  • dc.subject.keyword Early onset
  • dc.title Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion