The myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion composition

Fleta Soriano, Eric, 1983-; Smutná, Katarína, 1991-; Martinez, Javier P.; Lorca Oró, Cristina; Sadiq, S. Kashif; Mirambeau, Gilles; Lopez-Iglesias, Carmen; Bosch, Marta; Pol, Albert; Brönstrup, Mark; Díez Antón, Juana, 1962-; Meyerhans, Andreas

doi:http://dx.doi.org/10.1128/AAC.00739-17

The myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion composition

Citation

Fleta-Soriano E, Smutná K, Martínez JP, Lorca Oró C, Sadiq SK, Mirambeau G et al. The myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion composition. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00739-17. DOI: 10.1128/AAC.00739-17

Abstract

Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity. These effects are partially reversed by addition of palmitic acid, suggesting that inhibition of HIV envelope palmitoylation is one of the mechanisms of antiviral action.