The myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion composition

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dc.contributor.authorFleta Soriano, Eric, 1983-ca
dc.contributor.authorSmutná, Katarína, 1991-ca
dc.contributor.authorMartinez, Javier P.ca
dc.contributor.authorLorca Oró, Cristinaca
dc.contributor.authorSadiq, S. Kashifca
dc.contributor.authorMirambeau, Gillesca
dc.contributor.authorLopez-Iglesias, Carmenca
dc.contributor.authorBosch, Martaca
dc.contributor.authorPol, Albertca
dc.contributor.authorBrönstrup, Markca
dc.contributor.authorDíez Antón, Juana, 1962-ca
dc.contributor.authorMeyerhans, Andreasca
dc.date.accessioned2017-09-28T11:22:15Z
dc.date.issued2017
dc.description.abstractSoraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity. These effects are partially reversed by addition of palmitic acid, suggesting that inhibition of HIV envelope palmitoylation is one of the mechanisms of antiviral action.
dc.description.sponsorshipThe research was funded by the German Centre for Infection Research (DZIF), Spanish Ministry of Economy, Industry and Competitiveness and FEDER BES-2011-048569, Spanish Ministry of Economy, Industry and Competitiveness and FEDER SAF2013-46077-R SAF2016-75505-R, the Spanish Ministry of Economy, Industry and Competitiveness and FEDER BFU2016-80039-R and the Maria de Maetzu Programme for Units of Excellence in R&DMDM-2014-0370
dc.format.mimetypeapplication/pdfca
dc.identifier.citationFleta-Soriano E, Smutná K, Martínez JP, Lorca Oró C, Sadiq SK, Mirambeau G et al. The myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion composition. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00739-17. DOI: 10.1128/AAC.00739-17
dc.identifier.doihttp://dx.doi.org/10.1128/AAC.00739-17
dc.identifier.issn0066-4804
dc.identifier.urihttp://hdl.handle.net/10230/32829
dc.language.isoeng
dc.publisherAmerican Society for Microbiologyca
dc.relation.ispartofAntimicrob Agents Chemother. 2017 Jul 25;61(8):e00739-17
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/3PN/BES2011-048569
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/SAF2013-46077
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/SAF2016-75505-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/BFU2016-80039-R
dc.rights© American Society for Microbiology
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subject.otherVirus
dc.subject.otherMedicaments antivírics
dc.subject.otherVIH (Virus)
dc.titleThe myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion compositionca
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion

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