COVID-19 in children with down syndrome: data from the trisomy 21 Research Society Survey

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• dc.contributor.author Emes, David
• dc.contributor.author Hüls, Anke
• dc.contributor.author Baumer, Nicole
• dc.contributor.author Dierssen, Mara
• dc.contributor.author Puri, Shiela
• dc.contributor.author Russell, Lauren
• dc.contributor.author Sherman, Stephanie L.
• dc.contributor.author Strydom, Andre
• dc.contributor.author Bargagna, Stefania
• dc.contributor.author Brandão, Ana Cláudia
• dc.contributor.author Costa, Alberto C.S.
• dc.contributor.author Feany, Patrick T.
• dc.contributor.author Chicoine, Brian Allen
• dc.contributor.author Ghosh, Sujay
• dc.contributor.author Rebillat, Anne-Sophie
• dc.contributor.author Sgandurra, Giuseppina
• dc.contributor.author Valentini, Diletta
• dc.contributor.author Roher, Tilman R.
• dc.contributor.author Levin, Johannes
• dc.contributor.author Lakhanpaul, Monica
• dc.contributor.author Trisomy Research Society Covid-Initiative Study Group
• dc.date.accessioned 2022-04-01T09:19:14Z
• dc.date.available 2022-04-01T09:19:14Z
• dc.date.issued 2021
• dc.description.abstract Adults with Down Syndrome (DS) are at higher risk for severe outcomes of coronavirus disease 2019 (COVID-19) than the general population, but evidence is required to understand the risks for children with DS, which is necessary to inform COVID-19 shielding advice and vaccination priorities. We aimed to determine the epidemiological and clinical characteristics of COVID-19 in children with DS. Using data from an international survey obtained from a range of countries and control data from the United States, we compared the prevalence of symptoms and medical complications and risk factors for severe outcomes between DS and non-DS paediatric populations with COVID-19. Hospitalised COVID-19 patients <18 years with DS had a higher incidence of respiratory symptoms, fever, and several medical complications from COVID-19 than control patients without DS <18 years. Older age, obesity, and epilepsy were significant risk factors for hospitalisation among paediatric COVID-19 patients with DS, and age and thyroid disorder were significant risk factors for acute respiratory distress syndrome. Mortality rates were low in all paediatric COVID-19 patients (with and without DS), contrasting with previous findings in adults with DS (who exhibit higher mortality than those without DS). Children with DS are at increased risk for more severe presentations of COVID-19. Efforts should be made to ensure the comprehensive and early detection of COVID-19 in this population and to identify children with DS who present comorbidities that pose a risk for a severe course of COVID-19. Our results emphasize the importance of vaccinating children with DS as soon as they become eligible.
• dc.description.sponsorship This work is supported by grants from the following bodies: Down Syndrome Affiliates in Action, Down Syndrome Medical Interest Group-USA, GiGi’s Playhouse, Jerome Lejeune Foundation, LuMind IDSC Foundation, The Matthew Foundation, National Down Syndrome Society, National Task Group on Intellectual Disabilities and Dementia Practices. AH is supported by the HERCULES Center (NIEHS P30ES019776). The REDCap survey and database management system at Emory University was supported by Library Information Technology Services grant support (UL1 TR000424). MD is supported by the Centre for Genomic Regulation Severo Ochoa excellence grant, the CIBER of Rare Diseases, and DURSI 2017SGR595, and acknowledges the Spanish Ministry of Science, Innovation and Universities (MSIU) to the EMBL partnership, the Centro de Excelencia Severo Ochoa and CERCA (GenCat). AS is supported by the MRC (MR/S011277/1; MR/S005145/1; MR/R024901/1), Lumind IDSC, The LeJeune Foundation and the European Commission (H2020 SC1 Gene overdosage and comorbidities during the early lifetime in Down Syndrome GO-DS21- 848077). ML was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at UCL Great Ormond Street Institute of Child Health/Great Ormond Street Hospital NHS Foundation Trust). The Research Programme on Biomedical Informatics (GRIB) is a member of the Spanish National Bioinformatics Institute (INB), funded by ISCIII and EDER (PT17/0009/0014). The DCEXS is a “Unidad de Excelencia María de Maeztu”, funded by the AEI (CEX2018-000782-M). The GRIB is also supported by the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya (2017 SGR 00519). This study was also supported by the Fondo de Investigaciones Sanitario (FIS), Instituto de Salud Carlos III (PI18/00335 to MCI, PI14/01126 and PI17/01019 to JF), partly jointly funded by Fondo Europeo de Desarrollo Regional, Unión Europea, Una manera de hacer Europa; the Jérôme Lejeune Foundation (No. 1319 Cycle 2019B to MCI); the National Institutes of Health (NIA grants 1R01AG056850 - 01A1; R21AG056974 and R01AG061566 to JF); Departament de Salut de la Generalitat de Catalunya, Pla Estratègic de Recerca i Innovació en Salut (SLT006/17/00119 to JF); and Fundació La Marató de TV3 (20141210 to JF)
• dc.format.mimetype application/pdf
• dc.identifier.citation Emes D, Hüls A, Baumer N, Dierssen M, Puri S, Russell L et al. COVID-19 in children with down syndrome: data from the trisomy 21 Research Society Survey. J Clin Med. 2021 Oct 31;10(21):5125. DOI: 10.3390/jcm10215125
• dc.identifier.doi http://dx.doi.org/10.3390/jcm10215125
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/52810
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848077
• dc.rights © 2021 by David Emes et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.other COVID-19 (Malaltia)
• dc.subject.other Down, Síndrome de
• dc.subject.other Pediatria
• dc.title COVID-19 in children with down syndrome: data from the trisomy 21 Research Society Survey
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion