Association between chronic immune-mediated inflammatory diseases and cardiovascular risk

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• dc.contributor.author Baena Díez, Jose M.ca
• dc.contributor.author Garcia Gil, Mariaca
• dc.contributor.author Comas Cufí, Marcca
• dc.contributor.author Ramos, Rafelca
• dc.contributor.author Prieto-Alhambra, Danielca
• dc.contributor.author Salvador-González, Betlemca
• dc.contributor.author Elosua Llanos, Robertoca
• dc.contributor.author Dégano, Irene R.ca
• dc.contributor.author Peñafiel Muñoz, Judithca
• dc.contributor.author Grau Magaña, Mariaca
• dc.date.accessioned 2018-06-04T07:42:23Z
• dc.date.available 2018-06-04T07:42:23Z
• dc.date.issued 2017
• dc.description.sponsorship OBJECTIVE: To examine the association between chronic immune-mediated diseases (rheumatoid arthritis, systemic lupus erythematosus or the following chronic immune-mediated inflammatory diagnoses groups: inflammatory bowel diseases, inflammatory polyarthropathies, systemic connective tissue disorders and spondylopathies) and the 6-year coronary artery disease, stroke, cardiovascular disease incidence and overall mortality; and to estimate the population attributable fractions for all four end-points for each chronic immune-mediated inflammatory disease. METHODS: Cohort study of individuals aged 35-85 years, with no history of cardiovascular disease from Catalonia (Spain). The coded diagnoses of chronic immune-mediated diseases and cardiovascular diseases were ascertained and registered using validated codes, and date of death was obtained from administrative data. Cox regression models for each outcome according to exposure were fitted to estimate HRs in two models 1 : after adjustment for sex, age, cardiovascular risk factors and 2 further adjusted for drug use. Population attributable fractions were estimated for each exposure. RESULTS: Data were collected from 991 546 participants. The risk of cardiovascular disease was increased in systemic connective tissue disorders (model 1: HR=1.38 (95% CI 1.21 to 1.57) and model 2: HR=1.31 (95% CI 1.15 to 1.49)), rheumatoid arthritis (HR=1.43 (95% CI 1.26 to 1.62) and HR=1.31 (95% CI 1.15 to 1.49)) and inflammatory bowel diseases (HR=1.18 (95% CI 1.06 to 1.32) and HR=1.12 (95% CI 1.01 to 1.25)). The effect of anti-inflammatory treatment was significant in all instances (HR=1.50 (95% CI 1.24 to 1.81); HR=1.47 (95% CI 1.23 to 1.75); HR=1.43 (95% CI 1.19 to 1.73), respectively). The population attributable fractions for all three disorders were 13.4%, 15.7% and 10.7%, respectively. CONCLUSION: Systemic connective tissue disorders and rheumatoid arthritis conferred the highest cardiovascular risk and population impact, followed by inflammatory bowel diseases.
• dc.format.mimetype application/pdf
• dc.identifier.citation Baena-Díez JM, Garcia-Gil M, Comas-Cufí M, Ramos R, Prieto-Alhambra D, Salvador-González B. et al. Association between chronic immune-mediated inflammatory diseases and cardiovascular risk. Heart. 2018 Jan;104(2):119-126. DOI: 10.1136/heartjnl-2017-311279
• dc.identifier.doi http://dx.doi.org/10.1136/heartjnl-2017-311279
• dc.identifier.issn 1355-6037
• dc.identifier.uri http://hdl.handle.net/10230/34791
• dc.language.iso eng
• dc.publisher BMJ Publishing Groupca
• dc.relation.ispartof Heart. 2018 Jan;104(2):119-26
• dc.rights © BMJ Publishing Group. http://heart.bmj.com/content/104/2/119.long
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Arthritis
• dc.subject.keyword Cardiovascular disease
• dc.subject.keyword Connective Tissue Diseases
• dc.subject.keyword Inflammation
• dc.subject.keyword Inflammatory Bowel Diseases
• dc.subject.keyword Spondyloarthritis
• dc.subject.other Artritis
• dc.subject.other Sistema cardiovascular -- Malalties
• dc.title Association between chronic immune-mediated inflammatory diseases and cardiovascular riskca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion