Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study.

Huerta, José María; Chirlaque, María Dolores; Molina, Antonio J.; Amiano, Pilar; Martín Sánchez, Vicente; Fernández-Villa, Tania; Pérez-Gómez, Beatriz; Moreno, Víctor; Burgui, Rosana; Gómez-Acebo, Inés; Ramos-Lora, Manuel; Fernández-Tardón, Guillermo; Peiró, Rosana; Olmedo-Requena, Rocío; Pollan, Marina; Kogevinas, Manolis; Castaño Vinyals, Gemma; Aragonés, Núria; Navarro, Carmen

Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study.

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dc.contributor.author Huerta, José Maríaca
dc.contributor.author Chirlaque, María Doloresca
dc.contributor.author Molina, Antonio J.ca
dc.contributor.author Amiano, Pilarca
dc.contributor.author Martín Sánchez, Vicenteca
dc.contributor.author Fernández-Villa, Taniaca
dc.contributor.author Pérez-Gómez, Beatrizca
dc.contributor.author Moreno, Víctorca
dc.contributor.author Burgui, Rosanaca
dc.contributor.author Gómez-Acebo, Inésca
dc.contributor.author Ramos-Lora, Manuelca
dc.contributor.author Fernández-Tardón, Guillermoca
dc.contributor.author Peiró, Rosanaca
dc.contributor.author Olmedo-Requena, Rocíoca
dc.contributor.author Pollan, Marinaca
dc.contributor.author Kogevinas, Manolisca
dc.contributor.author Castaño Vinyals, Gemmaca
dc.contributor.author Aragonés, Núriaca
dc.contributor.author Navarro, Carmenca
dc.date.accessioned 2018-07-18T08:05:13Z
dc.date.available 2018-07-18T08:05:13Z
dc.date.issued 2017
dc.description.abstract BACKGROUND:Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study. METHODS: 428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals' catchment areas. A physical activity (PA) questionnaire was used to gather information on household and recreational activities, allowing estimation of PA volume (in metabolic equivalents (MET)-min/week). Participants also reported the intensity of working PA and daily sitting time. Questionnaire data on diet, lifestyles and clinical variables including Helicobacter pylori serology were available. Adjusted odds ratios (OR) of GAC were estimated for domains of physical activity, stratifying by sex, site (cardia vs. non-cardia), and Lauren classification (intestinal vs. diffuse). RESULTS: Household physical activity (HPA) showed a strong inverse association with GAC, observed for both cardia and non-cardia tumours. Risk of overall gastric cancer was 50% lower risk among participants in the highest HPA category (OR = 0.50, 95%CI: 0.38, 0.66). Recreational physical activity (RPA) was also associated with lower overall GAC risk (OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79). The protective effect of RPA was strongest for non-cardia tumours. Sedentary time was not related to GAC risk (p-trend = 0.392), but the potential protective effect of RPA was restricted to non-sedentary participants. CONCLUSIONS: Both household and recreational physical activities were independently related to lower GAC risk in the MCC-Spain study
dc.format.mimetype application/pdf
dc.identifier.citation Huerta JM, Chirlaque MD, Molina AJ, Amiano P, Martín V, Fernández-Villa T et al. Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study. PLoS One. 2017 Jul 6;12(7):e0179731. DOI: 10.1371/journal.pone.0179731
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0179731
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/35189
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)ca
dc.relation.ispartof PLoS One. 2017 Jul 6;12(7):e0179731
dc.rights Copyright © 2017 Huerta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.other Exercici
dc.subject.other Estómac -- Càncer
dc.title Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study.ca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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