Shared heritability and functional enrichment across six solid cancers

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• dc.contributor.author Jiang, Xia
• dc.contributor.author Kogevinas, Manolis
• dc.contributor.author Koutros, Stella
• dc.contributor.author Lindström, Sara
• dc.date.accessioned 2019-06-17T07:30:15Z
• dc.date.available 2019-06-17T07:30:15Z
• dc.date.issued 2019
• dc.description.abstract Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
• dc.format.mimetype application/pdf
• dc.identifier.citation Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y. et al. Shared heritability and functional enrichment across six solid cancers. Nat Commun. 2019 Jan 25;10(1):431.DOI: 10.1038/s41467-018-08054-4
• dc.identifier.doi http://dx.doi.org/10.1038/s41467-018-08054-4
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/41766
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nature Communications. 2019 Jan 25;10(1):431
• dc.rights Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Càncer -- Etiologia
• dc.subject.other Càncer -- Aspectes genètics
• dc.title Shared heritability and functional enrichment across six solid cancers
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion