Feasibility of collection and analysis of microbiome data in a longitudinal randomized trial of community gardening
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- dc.contributor.author Gascon Merlos, Mireia, 1984-
- dc.contributor.author Harrall, Kylie K.
- dc.contributor.author Beavers, Alyssa W.
- dc.contributor.author Glueck, Deborah H.
- dc.contributor.author Stanislawski, Maggie A.
- dc.contributor.author Alaimo, Katherine
- dc.contributor.author Villalobos, Angel
- dc.contributor.author Hebert, James R.
- dc.contributor.author Dexter, Kelsey
- dc.contributor.author Li, Kaigan
- dc.contributor.author Litt, Jill
- dc.date.accessioned 2021-04-21T11:00:14Z
- dc.date.issued 2020
- dc.description.abstract Aim: We explored the feasibility of collecting and analyzing human microbiome data in a longitudinal randomized controlled trial of community gardening. Methods & materials: Participants were randomly assigned to gardening (N = 8) or control (N = 8). Participants provided stool, mouth, hand and forehead microbiome samples at six timepoints. Analyses combined mixed models with Qiita output. Results: Participant satisfaction was high, with 75% of participants completing evaluations. While no microbial effects were statistically significant due to small sample size, the analysis pipeline utility was tested. Conclusion: Longitudinal collection and analysis of microbiome data in a community gardening randomized controlled trial is feasible. The analysis pipeline will be useful in larger studies for assessment of the pathway between microbiota, gardening and health outcomes.
- dc.description.sponsorship This study was funded by the University of Colorado Boulder Population Center (CUPC, J Litt, PI), through the National Institute of Child Health & Human Development of the NIH under award number P2CHD066613-06 and the Center for Microbiome Innovation at the University of California San Diego. We also received supplemental funding through the Clinical & Translational Research Center (CTRC) to cover all laboratory costs (J Litt, PI). M Gascon received a fellowship from the Societat Econòmica Barcelonesa d'Amics del País (SEBAP) in 2018, Barcelona (Catalonia), for her research stay at the University of Colorado to conduct the statistical analysis for this work. DH Glueck was supported, in part, by R01GM121-81 and R25 GM111901
- dc.format.mimetype application/pdf
- dc.identifier.citation Gascon M, Harall KK, Beavers AW, Glueck DH, Stanislawski MA, Alaimo K et al. Feasibility of collection and analysis of microbiome data in a longitudinal randomized trial of community gardening. Future Microbiol. 2020 May;5(8):633-648. DOI: 10.2217/fmb-2019-0195
- dc.identifier.doi http://dx.doi.org/10.2217/fmb-2019-0195
- dc.identifier.issn 1746-0913
- dc.identifier.uri http://hdl.handle.net/10230/47179
- dc.language.iso eng
- dc.publisher Future Medicine
- dc.rights © Future Medicine. https://dx.doi.org/10.2217/fmb-2019-0195
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Jardineria
- dc.subject.other Microbiologia -- Aspectes ambientals
- dc.subject.other Salut pública
- dc.title Feasibility of collection and analysis of microbiome data in a longitudinal randomized trial of community gardening
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion