Orexins and fear: implications for the treatment of anxiety disorders
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- dc.contributor.author Flores de los Heros, África, 1985-ca
- dc.contributor.author Saravia Santos, Rocio, 1988-ca
- dc.contributor.author Maldonado, Rafael, 1961-ca
- dc.contributor.author Berrendero Díaz, Fernando, 1971-ca
- dc.date.accessioned 2016-01-22T14:14:32Z
- dc.date.available 2016-09-01T02:00:05Z
- dc.date.issued 2015
- dc.description.abstract An understanding of the neurobiological mechanisms involved in the regulation of fear is essential for the development of new treatments for anxiety disorders, such as phobias, panic, and post-traumatic stress disorders (PTSD). Orexins, also known as hypocretins, are neuropeptides located exclusively in hypothalamic neurons that have extensive projections throughout the central nervous system. Although this system was initially believed to be primarily involved in the regulation of feeding behavior, recent studies have shown that orexins also modulate neural circuits implicated in the expression and extinction of fear memories. Here, we discuss recent findings involving orexins in anxiety disorders and current clinical trials using orexin ligands that could be applied to identify new therapies for diseases characterized by pathological fear.ca
- dc.description.sponsorship This work was supported by the Instituto de Salud Carlos III grants, #PI13/00042 and #RD12/0028/0023 (RTA-RETICS), by the Spanish Ministry of Science #SAF2011-29864 and #SAF2014-59648-P, National Plan on Drugs #2014I019, and the Catalan Government (SGR2014-1547).
- dc.format.mimetype application/pdfca
- dc.identifier.citation Flores Á, Saravia R, Maldonado R, Berrendero F. Orexins and fear: implications for the treatment of anxiety disorders. Trends in neurosciences. 2015;38(9):550-9. DOI: 10.1016/j.tins.2015.06.005ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.tins.2015.06.005
- dc.identifier.issn 0166-2236
- dc.identifier.uri http://hdl.handle.net/10230/25638
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Trends in neurosciences. 2015;38(9):550-9
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-29864
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2014-59648-P
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.tins.2015.06.005ca
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Amygdala
- dc.subject.keyword Anxiety
- dc.subject.keyword Fear
- dc.subject.keyword Orexin
- dc.subject.keyword Prefrontal cortex
- dc.subject.other Ansietatca
- dc.subject.other Orexinesca
- dc.title Orexins and fear: implications for the treatment of anxiety disordersca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca