Differences between the child and adult brain in the local functional structure of the cerebral cortex
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- dc.contributor.author Pujol, Jesús
- dc.contributor.author Blanco Hinojo, Laura, 1981-
- dc.contributor.author Macià, Dídac
- dc.contributor.author Martínez-Vilavella, Gerard
- dc.contributor.author Deus, Joan
- dc.contributor.author Pérez Solá, Victor
- dc.contributor.author Cardoner, Narcís
- dc.contributor.author Soriano Mas, Carles
- dc.contributor.author Sunyer Deu, Jordi
- dc.date.accessioned 2021-10-26T05:58:29Z
- dc.date.available 2021-10-26T05:58:29Z
- dc.date.issued 2021
- dc.description.abstract Imaging studies on neuronal network formation provide relevant information as to how the brain matures during adolescence. We used a novel imaging approach combining well-established MRI measures of local functional connectivity that jointly provide qualitatively different information relating to the functional structure of the cerebral cortex. To investigate the adolescent transition into adulthood, we comparatively assessed 169 preadolescents aged 8-12 years and 121 healthy adults. Whole-brain functional connectivity maps were generated using multi-distance measures of intracortical neural activity coupling defined within iso-distant local areas. Such Iso-Distant Average Correlation (IDAC) measures therefore represent the average temporal correlation of a given brain unit, or voxel, with other units situated at increasingly separated iso-distant intervals. The results indicated that between-group differences in the functional structure of the cerebral cortex are extensive and implicate part of the lateral prefrontal cortex, a medial frontal/anterior cingulate region, the superior parietal lobe extending to the somatosensory strip and posterior cingulate cortex, and local connections within the visual cortex, hippocampus, amygdala and insula. We thus provided detail of the cerebral cortex functional structure maturation during the transition to adulthood, which may serve to establish more accurate links between adolescent performance gains and cerebral cortex maturation. Remarkably, our study provides new information as to the cortical maturation processes in prefrontal areas relevant to executive functioning and rational learning, medial frontal areas playing an active role in the cognitive appraisal of emotion and anxiety, and superior parietal cortices strongly associated with bodily self-consciousness in the context of body image formation.
- dc.description.sponsorship This work was supported in part by the European Research Council under the ERC [grant number 268479] – the BREATHE project and the Carlos III Health Institute grants PI13/01958 and PI16/00889.
- dc.format.mimetype application/pdf
- dc.identifier.citation Pujol J, Blanco-Hinojo L, Macia D, Martínez-Vilavella G, Deus J, Pérez-Sola V, Cardoner N, Soriano-Mas C, Sunyer J. Differences between the child and adult brain in the local functional structure of the cerebral cortex. Neuroimage. 2021;237:118150. DOI: 10.1016/j.neuroimage.2021.118150
- dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2021.118150
- dc.identifier.issn 1053-8119
- dc.identifier.uri http://hdl.handle.net/10230/48811
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Neuroimage. 2021;237:118150
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/268479
- dc.rights © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0)
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0
- dc.subject.keyword Brain development
- dc.subject.keyword Cortical maturation
- dc.subject.keyword Frontal lobe
- dc.subject.keyword Functional connectivity
- dc.subject.keyword Functional structure
- dc.subject.keyword Neuronal network
- dc.title Differences between the child and adult brain in the local functional structure of the cerebral cortex
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion