Whole-blood gene expression profiles associated with mortality in community-acquired pneumonia
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- dc.contributor.author Viasus, Diego
- dc.contributor.author Simonetti, Antonella F.
- dc.contributor.author Nonell Mazelon, Lara, 1972-
- dc.contributor.author Vidal Orjuela, Óscar M.
- dc.contributor.author Meije, Yolanda
- dc.contributor.author Ortega Enciso, Lucía
- dc.contributor.author Arnal, Magdalena
- dc.contributor.author Bódalo-Torruella, Marta
- dc.contributor.author Sierra, Montserrat
- dc.contributor.author Rombauts, Alexander
- dc.contributor.author Abelenda-Alonso, Gabriela
- dc.contributor.author Blanchart, Gemma
- dc.contributor.author Gudiol, Carlota
- dc.contributor.author Carratalà, Jordi
- dc.date.accessioned 2024-05-02T07:24:26Z
- dc.date.available 2024-05-02T07:24:26Z
- dc.date.issued 2023
- dc.description.abstract (1) Background: Information regarding gene expression profiles and the prognosis of community-acquired pneumonia (CAP) is scarce. We aimed to examine the differences in the gene expression profiles in peripheral blood at hospital admission between patients with CAP who died during hospitalization and those who survived. (2) Methods: This is a multicenter study of nonimmunosuppressed adult patients who required hospitalization for CAP. Whole blood samples were obtained within 24 h of admission for genome-expression-profile analysis. Gene expression profiling identified both differentially expressed genes and enriched gene sets. (3) Results: A total of 198 samples from adult patients who required hospitalization for CAP were processed, of which 13 were from patients who died. Comparison of gene expression between patients who died and those who survived yielded 49 differentially expressed genes, 36 of which were upregulated and 13 downregulated. Gene set enrichment analysis (GSEA) identified four positively enriched gene sets in survivors, mainly associated with the interferon-alpha response, apoptosis, and sex hormone pathways. Similarly, GSEA identified seven positively enriched gene sets, associated with the oxidative stress, endoplasmic reticulum stress, oxidative phosphorylation, and angiogenesis pathways, in the patients who died. Protein–protein-interaction-network analysis identified FOS, CDC42, SLC26A10, EIF4G2, CCND3, ASXL1, UBE2S, and AURKA as the main gene hubs. (4) Conclusions: We found differences in gene expression profiles at hospital admission between CAP patients who died and those who survived. Our findings may help to identify novel candidate pathways and targets for potential intervention and biomarkers for risk stratification.
- dc.format.mimetype application/pdf
- dc.identifier.citation Viasus D, Simonetti AF, Nonell L, Vidal O, Meije Y, Ortega L, et al. Whole-Blood Gene Expression Profiles Associated with Mortality in Community-Acquired Pneumonia. Biomedicines. 2023 Feb 1;11(2):429. DOI: 10.3390/biomedicines11020429
- dc.identifier.doi http://dx.doi.org/10.3390/biomedicines11020429
- dc.identifier.issn 2227-9059
- dc.identifier.uri http://hdl.handle.net/10230/59974
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Biomedicines. 2023 Feb 1;11(2):429
- dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Community-acquired pneumonia
- dc.subject.keyword Mortality
- dc.subject.keyword Gene expression profile
- dc.subject.keyword Gene set enrichment analysis
- dc.title Whole-blood gene expression profiles associated with mortality in community-acquired pneumonia
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion