Axillary management in patients with breast cancer and positive axilla at diagnosis. Experience in a Spanish university hospital with a 5-year follow-up
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- dc.contributor.author Jiménez Gómez, Marta
- dc.contributor.author Loro-Pérez, Jorge
- dc.contributor.author Vega Benítez, Victor
- dc.contributor.author Hernández Hernández, Juan Ramón
- dc.contributor.author Argudo Aguirre, Nuria
- dc.date.accessioned 2024-03-08T07:05:51Z
- dc.date.available 2024-03-08T07:05:51Z
- dc.date.issued 2023
- dc.description.abstract Background: Axillary lymph node dissection (ALND) was the standard in breast cancer with axillary involvement until recently. Along with the number of metastatic nodes, axillary positivity was considered a main prognostic factor and scientific evidence shows that the administration of radiotherapy on ganglion areas decreases the risk of recurrence even in positive axilla. The objective of this study was to evaluate the axillary treatment in patients with positive axilla at diagnosis, the evolution of them over time, and to assess patient's follow-up with the aim of avoiding the morbidity associated with axillary dissection. Methods: A retrospective observational study of breast cancer patients diagnosed between 2010 and 2017 was performed. In total, 1,100 patients were studied, out of which 168 were women with clinically and histologically positive axilla at diagnosis. Seventy-six percent received primary chemotherapy and subsequent treatment with sentinel node biopsy, axillary dissection, or both. Patients with positive sentinel lymph node biopsy received either radiotherapy or lymphadenectomy depending on the year time they were diagnosed. Results: For 60 patients out of 168, neoadjuvant chemotherapy resulted in a complete pathological axillary response. Axillary recurrence was registered for six patients. No recurrence was detected in the biopsy group associated with radiotherapy. These results support the benefit of lymph node radiotherapy for patients with positive sentinel node biopsy after receiving primary chemotherapy. Conclusion: Sentinel node biopsy provides useful and reliable information about cancer staging and might prevent lymphadenectomy, leading to a decrease in morbidity. Pathological response to systemic treatment came out as the most important predictive factor of disease-free survival of breast cancer.
- dc.format.mimetype application/pdf
- dc.identifier.citation Jimenez-Gomez M, Loro-Pérez J, Vega-Benítez V, Hernández-Hernández JR, Aguirre NA. Axillary management in patients with breast cancer and positive axilla at diagnosis. Experience in a Spanish university hospital with a 5-year follow-up. J Cancer Res Ther. 2023 Jan-Mar;19(2):183-90. DOI: 10.4103/jcrt.jcrt_263_22
- dc.identifier.doi http://dx.doi.org/10.4103/jcrt.jcrt_263_22
- dc.identifier.issn 0973-1482
- dc.identifier.uri http://hdl.handle.net/10230/59356
- dc.language.iso eng
- dc.publisher Wolters Kluwer (LWW)
- dc.relation.ispartof J Cancer Res Ther. 2023 Jan-Mar;19(2):183-90
- dc.rights © 2022 Journal of Cancer Research and Therapeutics. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported (https://creativecommons.org/licenses/by-nc-sa/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
- dc.subject.keyword Axilla
- dc.subject.keyword Axillary dissection
- dc.subject.keyword Breast neoplasms
- dc.subject.keyword Follow-up studies
- dc.subject.keyword Lymph nodes
- dc.subject.keyword Lymphatic metastases
- dc.subject.keyword Neoadjuvant therapy
- dc.subject.keyword Sentinel lymph node biopsy
- dc.title Axillary management in patients with breast cancer and positive axilla at diagnosis. Experience in a Spanish university hospital with a 5-year follow-up
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion