Computational modelling of the cardiovascular system for the non-invasive diagnosis of portal hypertension

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  • dc.contributor.author Villanueva, M. Inmaculada
  • dc.contributor.author García Cañadilla, Patricia, 1985-
  • dc.contributor.author Camara, Oscar
  • dc.contributor.author Garcia-Criado, Angeles
  • dc.contributor.author Campreciós, Genís
  • dc.contributor.author Perez-Campuzano, Valeria
  • dc.contributor.author Hernandez-Gea, Virgina
  • dc.contributor.author Turon, Fanny
  • dc.contributor.author Baiges Aznar, Anna
  • dc.contributor.author Lopez Sainz, Angela
  • dc.contributor.author García-Pagan, Juan Carlos
  • dc.contributor.author Bijnens, Bart
  • dc.contributor.author Bernardino Perez, Gabriel
  • dc.date.accessioned 2024-03-01T07:32:41Z
  • dc.date.issued 2023
  • dc.description Comunicació presentada a 12th International Conference, FIMH 2023, celebrada del 19 al 22 de juny de 2023 a Lió, França.
  • dc.description.abstract Cirrhosis is a prevalent chronic liver disease that causes scarring of the liver, leading to altered mechanics and impaired function. One of its most severe complications is portal hypertension, characterised by an increase in portal vein pressure, associated with abnormal blood flow dynamics. Portal hypertension is usually diagnosed by measuring the hepatic venous pressure gradient (HVPG) through invasive catheterisation. Computational models can help to understand the causes of observed phenomena and assess certain variables that are challenging to measure without invasive procedures. Therefore, the aim of this study was to use a 0D model of the cardiovascular system to study portal hypertension and its haemodynamic effects in the circulation. A sensitivity analysis was conducted to assess the impact of different variables on the model. In addition, the model was personalised based on hepatic Doppler waveforms from two patients, one with elevated HVPG (and cirrhosis) and the other with normal HVPG (and hepatitis). The model-based haemodynamic parameters were compared to the invasive haemodynamic measurements. This study provides insight into how cirrhosis alters haemodynamics and demonstrates the potential of employing computational models of the cardiovascular system to understand haemodynamic changes in individual patients.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Villanueva MI, García Cañadilla P, Camara O, Garcia-Criado A, Camprecios G, Perez-Campuzano V, et al. Computational modelling of the cardiovascular system for the non-invasive diagnosis of portal hypertension. In: Bernard O, Clarysse P, Duchateau N, Ohayon J, Viallon M, eds. 12th International Conference, Functional Imaging and Modeling of the Heart, FIMH 2023; 2023 June 19-22; Lyon, France. Cham: Springer; 2023. p. 465-74. DOI: 10.1007/978-3-031-35302-4_48
  • dc.identifier.doi http://dx.doi.org/10.1007/978-3-031-35302-4_48
  • dc.identifier.issn 0302-9743
  • dc.identifier.uri http://hdl.handle.net/10230/59302
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Bernard O, Clarysse P, Duchateau N, Ohayon J, Viallon M, eds. 12th International Conference, Functional Imaging and Modeling of the Heart, FIMH 2023; 2023 June 19-22; Lyon, France. Cham: Springer; 2023. p. 465-74.
  • dc.rights © Springer This is a author's accepted manuscript of: Villanueva MI, García Cañadilla P, Camara O, Garcia-Criado A, Camprecios G; Perez-Campuzano, V, et al. Computational Modelling of the Cardiovascular System for the Non-invasive Diagnosis of Portal Hypertension. In: 12th International Conference, Functional Imaging and Modeling of the Heart, FIMH 2023; 2023 June 19-22; Lyon, France. Cham: Springer; 2023. p. 465-74. DOI: 10.1007/978-3-031-35302-4_48
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword 0D cardiovascular model
  • dc.subject.keyword Adult cardiology
  • dc.subject.keyword Cirrhosis
  • dc.subject.keyword Doppler ultrasound
  • dc.subject.keyword Optimisation
  • dc.subject.keyword Portal hypertension
  • dc.title Computational modelling of the cardiovascular system for the non-invasive diagnosis of portal hypertension
  • dc.type info:eu-repo/semantics/conferenceObject
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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Congressos (Departament de Tecnologies de la Informació i les Comunicacions)