Quantifying sensory thresholds along the migraine cycle: an exploratory longitudinal study

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• dc.contributor.author Ikumi Montserrat, Nara, 1986-
• dc.contributor.author Marti Marca, Angela
• dc.contributor.author Cerda-Company, Xim
• dc.contributor.author Vilà Balló, Adrià
• dc.contributor.author Gallardo López, Victor J.
• dc.contributor.author Caronna, Edoardo
• dc.contributor.author Alpuente, Alicia
• dc.contributor.author Pozo-Rosich, Patricia
• dc.date.accessioned 2025-11-18T06:41:21Z
• dc.date.available 2025-11-18T06:41:21Z
• dc.date.issued 2024
• dc.description.abstract Background. To date, a number of studies on migraine have cross-sectionally evaluated sensory sensitivity with aversion thresholds/scores along the migraine cycle, reporting a decreased tolerance to sensory stimuli in different sensory modalities. Our hypothesis was that patients with migraine would exhibit heightened sensitivity to sound, light, touch and smell on days where they reported greater headache intensity. Methods. This is an exploratory, longitudinal study, carried out over the course of 27 days. Aversion thresholds or scores to sound, light, touch and smell were quantified in six patients with migraine (11.33 ± 6.53 headache days/month). Results. Patients reported an increased sensitivity to light (padj = 0.0297), touch (padj = 0.0077), and smell (padj = 0.0201) on days with higher headache intensity. However, a greater sensitivity to sound on days with higher headache intensity was only reported when anxiety levels were high (padj = 1.4e−06). Interestingly, variable levels of tolerance to bothersome light over time can also influence the correlation between light sensitivity and headache intensity (padj = 1.4e−06). Conclusions. Based on the present findings, future longitudinal studies evaluating sensory threshold changes along the migraine cycle in patients with migraine should account for the increased tolerance to bothersome light over time as well as the effect of anxiety on auditory sensitivity.en
• dc.format.mimetype application/pdf
• dc.identifier.citation Ikumi N, Marti-Marca A, Torre-Suñe Adl, Cerda-Company X, Vilà-Balló A, Gallardo VJ, et al. Quantifying sensory thresholds along the migraine cycle: an exploratory longitudinal study. Cephalalgia. 2024 Feb;44(2):1-13. DOI: 10.1177/03331024241230279
• dc.identifier.doi http://dx.doi.org/10.1177/03331024241230279
• dc.identifier.issn 0333-1024
• dc.identifier.uri http://hdl.handle.net/10230/71907
• dc.language.iso eng
• dc.publisher SAGE Publications
• dc.relation.ispartof Cephalalgia. 2024 Feb;44(2):1-13
• dc.rights © International Headache Society 2024. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Allodyniaen
• dc.subject.keyword Aversionen
• dc.subject.keyword Discomforten
• dc.subject.keyword Osmophobiaen
• dc.subject.keyword Phonophobiaen
• dc.subject.keyword Photophobiaen
• dc.subject.keyword Sensory sensitivityen
• dc.title Quantifying sensory thresholds along the migraine cycle: an exploratory longitudinal studyen
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion