Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Marques, Irene
- dc.contributor.author Domènech-Panicello, Carola
- dc.contributor.author Binter, Anne-Claire
- dc.contributor.author Guxens Junyent, Mònica
- dc.contributor.author Felix, Janine F.
- dc.date.accessioned 2025-04-08T06:13:13Z
- dc.date.available 2025-04-08T06:13:13Z
- dc.date.issued 2025
- dc.description.abstract Background: Night shift work during pregnancy has been associated with differential DNA methylation in placental tissue, but no studies have explored this association in cord blood. We aimed to examine associations of maternal night shift work with cord blood DNA methylation. Methods: A total of 4487 mother-newborn pairs from 7 studies were included. Maternal night shift work during pregnancy was ascertained via questionnaires and harmonized into "any" versus "no". DNA methylation was measured in cord blood using the Illumina Infinium Methylation arrays. Robust linear regression models adjusted for relevant confounders were run in the individual cohorts, and results were meta-analyzed. Results: Maternal night shift work during pregnancy ranged from 3.4% to 26.3%. Three CpGs were differentially methylated in relation to maternal night shift work during pregnancy at a false discovery rate adjusted P < 0.05: cg10945885 (estimate (β) 0.38%, standard error (SE) 0.07), cg00773359 (β 0.25%, SE 0.05), and cg21836426 (β - 0.29%, SE 0.05). Associations of the identified CpGs were found in previous literature for gestational age and childhood and adolescent BMI. In a mouse model of prenatal jet lag exposure, information on offspring DNA methylation of ten homologous genes annotated to the 16 CpGs with P < 1 × 10-5 in our analysis was available, of which eight were associated (enrichment P: 1.62 × 10-11). Conclusion: Maternal night shift work during pregnancy was associated with newborn DNA methylation at 3 CpGs. Top findings overlapped with those in a mouse model of gestational jet lag. This work strengthens evidence that DNA methylation could be a marker or mediator of impacts of circadian rhythm disturbances.
- dc.format.mimetype application/pdf
- dc.identifier.citation Marques IF, Domènech-Panicello C, Geurtsen ML, Hoang TT, Richmond R, Polinski K, et al. Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium. Clin Epigenetics. 2025 Jan 22;17(1):12. DOI: 10.1186/s13148-024-01810-y
- dc.identifier.doi http://dx.doi.org/10.1186/s13148-024-01810-y
- dc.identifier.issn 1868-7075
- dc.identifier.uri http://hdl.handle.net/10230/70104
- dc.language.iso eng
- dc.publisher BioMed Central
- dc.relation.ispartof Clin Epigenetics. 2025 Jan 22;17(1):12
- dc.rights © The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cohort study
- dc.subject.keyword DNA methylation
- dc.subject.keyword Epigenetics
- dc.subject.keyword Night shift work
- dc.subject.keyword Pregnancy
- dc.title Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion