Phenotypic characterisation of early COPD: a prospective case-control study

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  • dc.contributor.author Cosío, Borja G.
  • dc.contributor.author Pascual Guàrdia, Sergi, 1979-
  • dc.contributor.author Borràs Santos, Alícia
  • dc.contributor.author Gea Guiral, Joaquim
  • dc.contributor.author García Aymerich, Judith
  • dc.contributor.author Faner, Rosa
  • dc.date.accessioned 2021-06-23T07:43:52Z
  • dc.date.available 2021-06-23T07:43:52Z
  • dc.date.issued 2020
  • dc.description.abstract The phenotypic characteristics of chronic obstructive pulmonary disease (COPD) in individuals younger than 50 years of age (early COPD) are not well defined. This prospective, multicentre, case-control study sought to describe these characteristics and compare them with those of smokers (≥10 pack-years) of similar age with normal spirometry (controls). We studied 92 cases (post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) <0.7) and 197 controls. Results were contrasted with participants with similar inclusion criteria recruited into the ECLIPSE and COPDGene cohorts. Cases had moderate airflow limitation (FEV1 71.3±20.8%) but were often symptomatic, used healthcare resources frequently, had air trapping (residual volume 150.6±55.5% ref.), had reduced diffusing capacity (84.2±20.7% ref.) and had frequent evidence of computed tomography (CT) emphysema (61%). Of note, less than half of cases (46%) had been previously diagnosed with COPD. Interestingly, they also often reported a family history of respiratory diseases and had been hospitalised because of respiratory problems before the age of 5 years more frequently than controls (12% versus 3%, p=0.009). By and large, these observations were reproduced when available in the ECLIPSE and COPDGene cohorts. These results show that early COPD is associated with substantial health impact and significant structural and functional abnormalities, albeit it is often not diagnosed (hence, treated). The fact that a sizeable proportion of patients with early COPD report a family history of respiratory diseases and/or early-life events (including hospitalisations before the age of 5 years) renders further support to the possibility of early-life origin of COPD.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Cosío BG, Pascual-Guardia S, Borras-Santos A, Peces-Barba G, Santos S, Vigil L, et al. Phenotypic characterisation of early COPD: a prospective case-control study. ERJ Open Res. 2020 Oct 5; 6(4): 00047-2020. DOI: 10.1183/23120541.00047-2020
  • dc.identifier.doi http://dx.doi.org/10.1183/23120541.00047-2020
  • dc.identifier.issn 2312-0541
  • dc.identifier.uri http://hdl.handle.net/10230/47961
  • dc.language.iso eng
  • dc.publisher European Respiratory Society
  • dc.rights Copyright ©ERS 2020. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. http://creativecommons.org/licenses/by-nc/4.0/
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.subject.other Fenotip
  • dc.subject.other Pulmons--Malalties obstructives
  • dc.title Phenotypic characterisation of early COPD: a prospective case-control study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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