Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection

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• dc.contributor.author Barmada, Anis
• dc.contributor.author Marchese, Domenica, 1986-
• dc.contributor.author Heyn, Holger
• dc.contributor.author Rodríguez Ubreva, Javier
• dc.date.accessioned 2024-01-17T08:23:02Z
• dc.date.available 2024-01-17T08:23:02Z
• dc.date.issued 2023
• dc.description.abstract In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. Here, we performed single-cell analysis of peripheral blood mononuclear cells from patients with three major autoimmune diseases (rheumatoid arthritis, psoriasis, or multiple sclerosis) during SARS-CoV-2 infection. We observed compositional differences between the autoimmune disease groups coupled with altered patterns of gene expression, transcription factor activity, and cell-cell communication that substantially shape the immune response under SARS-CoV-2 infection. While enrichment of HLA-DRlow CD14+ monocytes was observed in all three autoimmune disease groups, type-I interferon signaling as well as inflammatory T cell and monocyte responses varied widely between the three groups of patients. Our results reveal disturbed immune responses to SARS-CoV-2 in patients with pre-existing autoimmunity, highlighting important considerations for disease treatment and follow-up.
• dc.description.sponsorship This research was funded/supported by the R+D+i project of the Spanish Ministry of Science and Innovation (grant number PID2020-117212RB-I00/ MICIN/AEI/10.13039/501100011033), the Chan Zuckerberg Initiative (grant 2020–216799) and Wellcome Sanger core funding (WT206194). This publication has been supported by the Unstoppable campaign of the Josep Carreras Leukaemia Foundation. B.G., F.J.C.-N., and N.K.W. were funded by Wellcome (206328/Z/17/Z), the MRC (MR/S036113/1), and the Aging Biology Foundation.
• dc.format.mimetype application/pdf
• dc.identifier.citation Barmada A, Handfield LF, Godoy-Tena G, de la Calle-Fabregat C, Ciudad L, Arutyunyan A, et al. Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection. Eur J Immunol. 2023 Oct 6:e2350633. DOI: 10.1002/eji.202350633
• dc.identifier.doi http://dx.doi.org/10.1002/eji.202350633
• dc.identifier.issn 0014-2980
• dc.identifier.uri http://hdl.handle.net/10230/58740
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Eur J Immunol. 2023 Oct 6:e2350633
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-117212RB-I00
• dc.rights © 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Autoimmunity
• dc.subject.keyword COVID-19
• dc.subject.keyword Multiple sclerosis
• dc.subject.keyword Psoriasis
• dc.subject.keyword Rheumatoid arthritis
• dc.title Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion