Influence of early postoperative basal insulin treatment and post-transplant diabetes mellitus risk on health-related quality of life in kidney tTransplant recipients-an analysis of data from a randomized controlled trial

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Odler, Balazs
• dc.contributor.author Huemer, Matthias
• dc.contributor.author Schwaiger, Elisabeth
• dc.contributor.author Borenich, Andrea
• dc.contributor.author Kurnikowski, Amelie
• dc.contributor.author Krall, Marcell
• dc.contributor.author Hafner-Giessauf, Hildegard
• dc.contributor.author Eleftheriadis, Georgios
• dc.contributor.author Bachmann, Friderike
• dc.contributor.author Faura, Anna
• dc.contributor.author Pérez-Sáez, María José
• dc.contributor.author Pascual Santos, Julio
• dc.contributor.author Budde, Klemens
• dc.contributor.author Rosenkranz, Alexander R.
• dc.contributor.author Hecking, Manfred
• dc.contributor.author Eller, Kathrin
• dc.date.accessioned 2024-06-04T06:20:23Z
• dc.date.available 2024-06-04T06:20:23Z
• dc.date.issued 2023
• dc.description.abstract Health-related quality of life (HRQOL) improves after kidney transplantation (KT) but declines over time. Studies on the effect of early postoperative basal insulin therapy on HRQOL after KT, especially KTRs at high risk of developing post-transplant diabetes mellitus (PTDM) are missing. Data from a randomized controlled trial on 148 non-diabetic KTRs were analyzed. HRQOL using the KDQOL-SF™ was compared in KTRs who either received early postoperative basal insulin therapy or standard-of-care and in KTRs at risk of developing PTDM. Determinants of HRQOL outcomes were investigated using multivariable linear regression analysis. In total, 148 patients completed the KDQOL-SF at baseline. Standard-of-care or early basal insulin therapy after KT did not influence HRQOL. Overall, KT improved the mental (MCS) and physical component summary (PCS) scores at 6-month after KT, which remained stable during further follow-up visits. However, patients at high-risk for PTDM had significantly greater impairment in the PCS score (baseline, 24 months) without differences in MCS scores. In the multivariable regression analysis, allograft function and hemoglobin levels were associated with decreased MCS and PCS scores, respectively. A limitation of the study is the fact that only around 50% of the ITP-NODAT study patients participated in the HRQOL evaluation. Still, our data clearly show that early basal insulin therapy does not affect HRQOL after KT but is negatively influenced by classical clinical factors and PTDM-risk at 24 months after KT. The latter might be influenced by older age.
• dc.format.mimetype application/pdf
• dc.identifier.citation Odler B, Huemer M, Schwaiger E, Borenich A, Kurnikowski A, Krall M, et al. Influence of early postoperative basal insulin treatment and post-transplant diabetes mellitus risk on health-related quality of life in kidney tTransplant recipients-an analysis of data from a randomized controlled trial. Transpl Int. 2023 Aug 3;36:11370. DOI: 10.3389/ti.2023.11370
• dc.identifier.doi http://dx.doi.org/10.3389/ti.2023.11370
• dc.identifier.issn 0934-0874
• dc.identifier.uri http://hdl.handle.net/10230/60332
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Transpl Int. 2023 Aug 3;36:11370
• dc.rights © 2023 Odler, Huemer, Schwaiger, Borenich, Kurnikowski, Krall, Hafner-Giessauf, Eleftheriadis, Bachmann, Faura, José Pérez-Sáez, Pascual, Budde, Rosenkranz, Hecking and Eller. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword HRQOL
• dc.subject.keyword PTDM
• dc.subject.keyword Clinical study
• dc.subject.keyword Insulin
• dc.subject.keyword Kidney transplantation
• dc.title Influence of early postoperative basal insulin treatment and post-transplant diabetes mellitus risk on health-related quality of life in kidney tTransplant recipients-an analysis of data from a randomized controlled trial
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion