Sculpting the labyrinth: Morphogenesis of the developing inner ear

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• dc.contributor.author Alsina i Español, Bertaca
• dc.contributor.author Whitfield, Tanya T.ca
• dc.date.accessioned 2017-07-06T07:44:22Z
• dc.date.available 2017-07-06T07:44:22Z
• dc.date.issued 2017
• dc.description.abstract The vertebrate inner ear is a precision sensory organ, acting as both a microphone to receive sound and an accelerometer to detect gravity and motion. It consists of a series of interlinked, fluid-filled chambers containing patches of sensory epithelia, each with a specialised function. The ear contains many different differentiated cell types with distinct morphologies, from the flask-shaped hair cells found in thickened sensory epithelium, to the thin squamous cells that contribute to non-sensory structures, such as the semicircular canal ducts. Nearly all cell types of the inner ear, including the afferent neurons that innervate it, are derived from the otic placode, a region of cranial ectoderm that develops adjacent to the embryonic hindbrain. As the ear develops, the otic epithelia grow, fold, fuse and rearrange to form the complex three-dimensional shape of the membranous labyrinth. Much of our current understanding of the processes of inner ear morphogenesis comes from genetic and pharmacological manipulations of the developing ear in mouse, chicken and zebrafish embryos. These traditional approaches are now being supplemented with exciting new techniques—including force measurements and light-sheet microscopy—that are helping to elucidate the mechanisms that generate this intricate organ system.
• dc.description.sponsorship Work in the Whitfield lab is funded by the BBSRC (BB/M01021X/1) and work in the Alsina lab is funded by the MINNECO BFU2014-53203.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Alsina i Español B, Whitfield TT. Sculpting the labyrinth: Morphogenesis of the developing inner ear. Seminars in Cell & Developmental Biology. 2017; 65: 47-59. DOI: 10.1016/j.semcdb.2016.09.015
• dc.identifier.doi http://dx.doi.org/10.1016/j.semcdb.2016.09.015
• dc.identifier.issn 1084-9521
• dc.identifier.uri http://hdl.handle.net/10230/32512
• dc.language.iso eng
• dc.publisher Elsevierca
• dc.relation.ispartof Seminars in Cell & Developmental Biology. 2017;65:47-59
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-53203
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.semcdb.2016.09.015. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Inner ear
• dc.subject.keyword Otic placode
• dc.subject.keyword Neurogenesis
• dc.subject.keyword Sensory hair cell
• dc.subject.keyword Semicircular canal
• dc.subject.keyword Morphogenesis
• dc.title Sculpting the labyrinth: Morphogenesis of the developing inner earca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion