Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential

Saus Martínez, Ester; Iraola Guzmán, Susana; Willis, Jesse R.; Brunet-Vega, Anna; Gabaldón Estevan, Juan Antonio, 1973-

Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential

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dc.contributor.author Saus Martínez, Ester
dc.contributor.author Iraola Guzmán, Susana
dc.contributor.author Willis, Jesse R.
dc.contributor.author Brunet-Vega, Anna
dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
dc.date.accessioned 2020-03-31T07:46:20Z
dc.date.available 2020-03-31T07:46:20Z
dc.date.issued 2019
dc.description.abstract The gastrointestinal tract harbors most of the microbiota associated with humans. In recent years, there has been a surge of interest in assessing the relationships between the gut microbiota and several gut alterations, including colorectal cancer. Changes in the gut microbiota in patients suffering colorectal cancer suggest a possible role of host-microbe interactions in the origin and development of this malignancy and, at the same time, open the door for novel ways of preventing, diagnosing, or treating this disease. In this review we survey current knowledge on the healthy microbiome of the gut and how it is altered in colorectal cancer and other related disease conditions. In describing past studies we will critically assess technical limitations of different approaches and point to existing challenges in microbiome research. We will have a special focus on host-microbiome interaction mechanisms that may be important to explain how dysbiosis can lead to chronic inflammation and drive processes that influence carcinogenesis and tumor progression in colon cancer. Finally, we will discuss the potential of recent developments of novel microbiota-based therapeutics and diagnostic tools for colorectal cancer.
dc.description.sponsorship This work was supported by grants from COST (European Cooperation in Science and Technology), COST Action CA17118; from the Spanish Ministry of Economy, Industry, and Competitiveness (MEIC) for the EMBL partnership, and grants ‘Centro de Excelencia Severo Ochoa’ SEV-2012-0208, and BFU2015-67107 cofounded by European Regional Development Fund; from the CERCA Programme/Generalitat de Catalunya; from the Catalan Research Agency (AGAUR) SGR857, and grants from the European Union’s Horizon 2020 research and innovation programme under the grant agreement ERC-2016-724173, and the Marie Sklodowska-Curie grant agreement No H2020-MSCA-ITN-2014-642095; and from Instituto Nacional de Bioinformatica (INB, grant PT17/0009/0023 - ISCIII-SGEFI/ERDF).
dc.format.mimetype application/pdf
dc.identifier.citation Saus E, Iraola-Guzmán S, Willis JR, Brunet-Vega A, Gabaldón T. Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential. Mol Aspects Med. 2019; 69:93-106. DOI: 10.1016/j.mam.2019.05.001
dc.identifier.doi http://dx.doi.org/10.1016/j.mam.2019.05.001
dc.identifier.issn 0098-2997
dc.identifier.uri http://hdl.handle.net/10230/44120
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Mol Aspects Med. 2019; 69:93-106
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-67107
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/724173
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/642095
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0
dc.subject.keyword Colon
dc.subject.keyword Colorectal cancer
dc.subject.keyword Gut microbiome
dc.subject.keyword Microbiota
dc.title Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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