Electrical impedance characterization of normal and cancerous human hepatic tissue
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- dc.contributor.author Laufer, Shlomica
- dc.contributor.author Ivorra Cano, Antoni, 1974-ca
- dc.contributor.author Reuter, Victor E.ca
- dc.contributor.author Rubinsky, Borisca
- dc.contributor.author Solomon, Stephen B.ca
- dc.date.accessioned 2016-05-05T13:54:46Z
- dc.date.available 2016-05-05T13:54:46Z
- dc.date.issued 2010ca
- dc.description.abstract The four-electrode method was used to measure the ex-vivo complex electrical impedance of tissues from14 hepatic tumors and the surrounding normal liver from 6 patients. Measurements were done in the frequency range of 1 kHz - 400 kHz. It was found that the conductivity of the tumor tissue was much higher than that of the normal liver tissue in this frequency range (from 0.14 ±0.06 S m−1 vs. 0.03 ±0.01 S m−1 at 1 kHz to 0.25 ±0.06 S m−1 vs. 0.15 ±0.03 S m−1 at 400 kHz). Cole-Cole models were estimated from the experimental data and the four parameters (ρ0,ρ∞,α,fc) were obtained using a least squares fit algorithm. The Cole-Cole parameters for cancerous and normal liver are (9 ±4 Ω m−1,2.2±0.7 Ω m−1,0.5±0.2,140±103 kHz) and (50±28 Ω m−1,3.2 ±0.6 Ω m−1,0.64±0.04,10±7 kHz), respectively. These data can contribute to developing bioelectric applications for tissue diagnostics, and in tissue treatment planning with electrical fields such as radiofrequency tissue ablation, electrochemotherapy and gene therapy with reversible electroporation, nanoscale pulsing and irreversible electroporation.en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Laufer S, Ivorra A, Reuter VE, Rubinsky B, Solomon SB. Electrical impedance characterization of normal and cancerous human hepatic tissue. Physiol Meas. 2010;31(7):995-1009. DOI:10.1088/0967-3334/31/7/009ca
- dc.identifier.doi http://dx.doi.org/10.1088/0967-3334/31/7/009
- dc.identifier.issn 0967-3334ca
- dc.identifier.uri http://hdl.handle.net/10230/26251
- dc.language.iso engca
- dc.publisher IOP Publishingca
- dc.relation.ispartof Physiological measurement. 2010;31(7):995-1009.
- dc.rights © 2010 Institute of Physics and Engineering in Medicineca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Enginyeria biomèdicaca
- dc.subject.other Electrofisiologiaca
- dc.subject.other Impedància (Electricitat)ca
- dc.title Electrical impedance characterization of normal and cancerous human hepatic tissueca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca