Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD

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  • dc.contributor.author Atasoy, Selen
  • dc.contributor.author Roseman, Leor
  • dc.contributor.author Kaelen, Mendel
  • dc.contributor.author Kringelbach, Morten L.
  • dc.contributor.author Deco, Gustavo
  • dc.contributor.author Carhart-Harris, Robin L.
  • dc.date.accessioned 2019-04-08T08:45:50Z
  • dc.date.available 2019-04-08T08:45:50Z
  • dc.date.issued 2017
  • dc.description.abstract Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used ’connectome-harmonic decomposition’, a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.
  • dc.description.sponsorship The authors would like to thank Andrea Insabato for valuable discussions on significance analysis. This work and S.A. are supported by Programa Beatriu de Pinos 2014 BP-B 00270. L.R., M.K. and R.L.C.H. are supported by Beckley foundation. G.D. is supported by the ERC Advanced Grant: DYSTRUCTURE (no 295129), by the Spanish Research Project PSI2016-75688-P (AEI/FEDER), by the European Union’s Horizon 2020 research and innovation programme under grant agreement no 720270 (HBP SGA1). M.L.K. is supported by the ERC Grant: CAREGIVING (no 615539). Part of this work was supported by Walacea crowd funding campaign.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Atasoy S, Roseman L, Kaelen M, Kringelbach ML, Deco G, Carhart-Harris RL. Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Sci Rep. 2017 Dec 15;7:17661. DOI: 10.1038/s41598-017-17546-0
  • dc.identifier.doi http://dx.doi.org/10.1038/s41598-017-17546-0
  • dc.identifier.issn 2045-2322
  • dc.identifier.uri http://hdl.handle.net/10230/37058
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Scientific Reports. 2017 Dec 15;7:17661.
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
  • dc.relation.projectID info:eu-repo/grantAgreement/EC//FP7/615539
  • dc.rights © Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Biomarkers
  • dc.subject.keyword Consciousness
  • dc.subject.keyword Dynamical systems
  • dc.subject.keyword Neuroscience
  • dc.title Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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