CLA+ memory T cells in atopic dermatitis: CLA+ T cells and atopic dermatitis

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• dc.contributor.author Sans-de San Nicolás, Lídia
• dc.contributor.author Czarnowicki, Tali
• dc.contributor.author Akdis, Mübeccel
• dc.contributor.author Pujol Vallverdú, Ramon Maria
• dc.contributor.author Lozano-Ojalvo, Daniel
• dc.contributor.author Leung, Donald Y. M.
• dc.contributor.author Guttman-Yassky, Emma
• dc.contributor.author Santamaria-Babí, Luis F.
• dc.date.accessioned 2024-04-24T06:48:19Z
• dc.date.available 2024-04-24T06:48:19Z
• dc.date.issued 2024
• dc.description.abstract Circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.
• dc.format.mimetype application/pdf
• dc.identifier.citation Nicolàs LSS, Czarnowicki T, Akdis M, Pujol RM, Lozano-Ojalvo D, Leung DYM, et al. CLA+ memory T cells in atopic dermatitis: CLA+ T cells and atopic dermatitis. Allergy. 2024 Jan;79(1):15-25. DOI: 10.1111/all.15816
• dc.identifier.doi http://dx.doi.org/10.1111/all.15816
• dc.identifier.issn 0105-4538
• dc.identifier.uri http://hdl.handle.net/10230/59881
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Allergy. 2024 Jan;79(1):15-25
• dc.rights © 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword CLA+ T cells
• dc.subject.keyword Atopic dermatitis
• dc.subject.keyword Biomarker
• dc.subject.keyword Skin-homing
• dc.subject.keyword Translational
• dc.title CLA+ memory T cells in atopic dermatitis: CLA+ T cells and atopic dermatitis
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion