Altered resting-state whole-brain functional networks of neonates with intrauterine growth restriction

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• dc.contributor.author Batalle, Dafnisca
• dc.contributor.author Muñoz-Moreno, Emmaca
• dc.contributor.author Tornador Antolin, Cristian, 1979-ca
• dc.contributor.author Bargallo, Nuriaca
• dc.contributor.author Deco, Gustavoca
• dc.contributor.author Eixarch, Elisendaca
• dc.contributor.author Gratacós Solsona, Eduardca
• dc.date.accessioned 2016-07-15T09:54:08Z
• dc.date.available 2017-01-30T03:00:03Z
• dc.date.issued 2016ca
• dc.description.abstract The feasibility to use functional MRI (fMRI) during natural sleep to assess low-frequency basal brain activity fluctuations in human neonates has been demonstrated, although its potential to characterise pathologies of prenatal origin has not yet been exploited. In the present study, we used intrauterine growth restriction (IUGR) as a model of altered neurodevelopment due to prenatal condition to show the suitability of brain networks to characterise functional brain organisation at neonatal age. Particularly, we analysed resting-state fMRI signal of 20 neonates with IUGR and 13 controls, obtaining whole-brain functional networks based on correlations of blood oxygen level-dependent (BOLD) signal in 90 grey matter regions of an anatomical atlas (AAL). Characterisation of the networks obtained with graph theoretical features showed increased network infrastructure and raw efficiencies but reduced efficiency after normalisation, demonstrating hyper-connected but sub-optimally organised IUGR functional brain networks. Significant association of network features with neurobehavioral scores was also found. Further assessment of spatiotemporal dynamics displayed alterations into features associated to frontal, cingulate and lingual cortices. These findings show the capacity of functional brain networks to characterise brain reorganisation from an early age, and their potential to develop biomarkers of altered neurodevelopment.
• dc.description.sponsorship This work was supported by grants from: Obra Social “la Caixa”, Barcelona, Spain; The Cerebra Foundation for the Brain-Injured Child, Carmarthen, Wales, UK; Fundacion Dexeus, Barcelona, Spain; Project PI13/01018 and Sara Borrell grant CD11/00048 to E.M., “Integrado en el Plan Nacional de I+D+I y cofinanciado por el ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER). Unión Europea. “Otra manera de hacer Europa””. G.D. thanks support of the advanced ERC grant DYSTRUCTURE.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Batalle D, Muñoz-Moreno E, Tornador C, Bargallo N, Deco G, Eixararc E, Gratacos E. Altered resting-state whole-brain functional networks of neonates with intrauterine growth restriction. Cortex. 2016;77:119-31. DOI: 10.1016/j.cortex.2016.01.012ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.cortex.2016.01.012
• dc.identifier.issn 0010-9452ca
• dc.identifier.uri http://hdl.handle.net/10230/27063
• dc.language.iso engca
• dc.publisher Elsevierca
• dc.relation.ispartof Cortex. 2016;77:119-31
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129ca
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.cortex.2016.01.012ca
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Brain mapping
• dc.subject.keyword fMRI
• dc.subject.keyword Newborn
• dc.subject.keyword Fetal growth retardation
• dc.subject.keyword Connectomics
• dc.title Altered resting-state whole-brain functional networks of neonates with intrauterine growth restrictionca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/acceptedVersionca