Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: The role of gender (EMITRAL study).

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• dc.contributor.author Torres, Armandoca
• dc.contributor.author Crespo Barrio, Martaca
• dc.contributor.author Mir Fontana, M. Luisaca
• dc.contributor.author Gómez Alamillo, Carlosca
• dc.date.accessioned 2016-07-22T06:56:25Z
• dc.date.available 2016-07-22T06:56:25Z
• dc.date.issued 2016
• dc.description.abstract BACKGROUND AND OBJECTIVES: The relationship between mineral metabolism disorders, bone fractures and vascular calcifications in kidney transplant recipients has not been established. METHOD: We performed a cross-sectional study in 727 stable recipients from 28 Spanish transplant clinics. Mineral metabolism parameters, the semi-quantification of vertebral fractures and abdominal aortic calcifications were determined centrally. RESULTS: Vitamin D deficiency (25OHD3<15ng/ml) was more common in female recipients at CKD-T stages I-III (29.6% vs 44.4%; p=0.003). The inverse and significant correlation between 25OHD3 and PTH was gender-specific and women exhibited a steeper slope than men (p=0.01). Vertebral fractures (VFx) with deformity grade ≥2 were observed in 15% of recipients. Factors related to VFx differed by gender; in males, age (OR 1.04; 95% CI 1.01-1.06) and CsA treatment (OR: 3.2; 95% CI: 1.6-6.3); in females, age (OR 1.07; 95% CI: 1.03-1.12) and PTH levels (OR per 100pg/ml increase: 1.27; 95% CI: 1.043-1.542). Abdominal aortic calcifications were common (67.2%) and related to classical risk factors but not to mineral metabolism parameters. CONCLUSIONS: Vitamin D deficiency is more common among female kidney transplant recipients at earlier CKD-T stages, and it contributes to secondary hyperparathyroidism. Prevalent vertebral fractures are only related to high serum PTH levels in female recipients.ca
• dc.format.mimetype application/pdfca
• dc.identifier.citation Torres A, Torregrosa V, Marcen R, Campistol JM, Arias M, Hernández D. et al. Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: The role of gender (EMITRAL study). Nefrologia. 2016 May-Jun;36(3):255-67. doi: 10.1016/j.nefro.2016.03.004ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.nefro.2016.03.004
• dc.identifier.issn 0211-6995
• dc.identifier.uri http://hdl.handle.net/10230/27102
• dc.language.iso engca
• dc.publisher Sociedad Española de Nefrologiaca
• dc.relation.ispartof Nefrologia. 2016 May-Jun;36(3):255-67
• dc.rights 0211-6995/© 2016 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ca
• dc.subject.other Metabolisme -- Trastornsca
• dc.subject.other Ronyons -- Trasplantacióca
• dc.title Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: The role of gender (EMITRAL study).ca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca