The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime (HADES) framework

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• dc.contributor.author Vohryzek, Jakub
• dc.contributor.author Cabral, Joana
• dc.contributor.author Timmermann, Christopher
• dc.contributor.author Atasoy, Selen
• dc.contributor.author Roseman, Leor
• dc.contributor.author Nutt, David J.
• dc.contributor.author Carhart-Harris, Robin L.
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Kringelbach, Morten L.
• dc.date.accessioned 2025-06-16T08:34:50Z
• dc.date.available 2025-06-16T08:34:50Z
• dc.date.issued 2024
• dc.description.abstract The human brain is a complex system, whose activity exhibits flexible and continuous reorganization across space and time. The decomposition of whole-brain recordings into harmonic modes has revealed a repertoire of gradient-like activity patterns associated with distinct brain functions. However, the way these activity patterns are expressed over time with their changes in various brain states remains unclear. Here, we investigate healthy participants taking the serotonergic psychedelic N,N-dimethyltryptamine (DMT) with the Harmonic Decomposition of Spacetime (HADES) framework that can characterize how different harmonic modes defined in space are expressed over time. HADES demonstrates significant decreases in contributions across most low-frequency harmonic modes in the DMT-induced brain state. When normalizing the contributions by condition (DMT and non-DMT), we detect a decrease specifically in the second functional harmonic, which represents the uni- to transmodal functional hierarchy of the brain, supporting the leading hypothesis that functional hierarchy is changed in psychedelics. Moreover, HADES’ dynamic spacetime measures of fractional occupancy, life time and latent space provide a precise description of the significant changes of the spacetime hierarchical organization of brain activity in the psychedelic state.
• dc.description.sponsorship Jakub Vohryzek is supported by EU H2020 FET Proactive project Neurotwin (101017716). Morten L. Kringelbach is supported by the European Research Council Consolidator Grant: CAREGIVING (615539), Pettit Foundation, Carlsberg Foundation, Center for Music in the Brain, and the Danish National Research Foundation (DNRF117). Joana Cabral is supported by ‘la Caixa’ Foundation, Spain (LCF/BQ/PR22/11920014) and the Portuguese Foundation for Science and Technology, Portugal (UIDB/50026/2020 and UIDP/50026/2020). Gustavo Deco is supported by the Spanish Research Project (PSI2016-75688-P, Agencia Estatal de Investigación/Fondo Europeo de Desarrollo Regional, European Union), the European Union's Horizon 2020 Research and Innovation Programme (720270 (Human Brain Project [HBP] SGA1) and 785907 (HBP SGA2)), and the Catalan Agency for Management of University and Research Grants (2017 SGR 1545).
• dc.format.mimetype application/pdf
• dc.identifier.citation Vohryzek J, Cabral J, Timmermann C, Atasoy S, Roseman L, Nutt DJ, et al. The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime (HADES) framework. Natl Sci Rev. 2024 May;11(5):nwae124. DOI: 10.1093/nsr/nwae124
• dc.identifier.doi http://dx.doi.org/10.1093/nsr/nwae124
• dc.identifier.issn 2095-5138
• dc.identifier.uri http://hdl.handle.net/10230/70694
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof National Science Review. 2024 May;11(5):nwae124
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101017716
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/615539
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
• dc.rights © The Author(s) 2024. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Spatio-temporal brain dynamics
• dc.subject.keyword DMT
• dc.subject.keyword Harmonic modes
• dc.title The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime (HADES) framework
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion