Bladder cancer molecular taxonomy: summary from a consensus meeting
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- dc.contributor.author Lerner, Seth Paulca
- dc.contributor.author McConkey, Davidca
- dc.contributor.author Hoadley, Katherine A.ca
- dc.contributor.author Chan, Keith S.ca
- dc.contributor.author Kim, William Y.ca
- dc.contributor.author Radvanyi, Françoisca
- dc.contributor.author Höglund, Mattiasca
- dc.contributor.author Real, Francisco X.ca
- dc.date.accessioned 2016-05-12T14:56:19Z
- dc.date.available 2016-05-12T14:56:19Z
- dc.date.issued 2016
- dc.description.abstract The advent of Omics technologies has been key to the molecular subclassification of urothelial bladder cancer. Several groups have used different strategies to this aim, with partially overlapping findings. The meeting at the Spanish National Cancer Research Center-CNIO was held to discuss such classifications and reach consensus where appropriate. After updated presentations on the work performed by the teams attending the meeting, a consensus was reached regarding the existence of a group of Basal-Squamous-like tumors – designated BASQ – charaterized the high expression of KRT5/6 and KRT14 and low/undetectable expression of FOXA1 and GATA3. An additional tumor subgroup with urothelial differentiation features was recognized whose optimal molecular definition is required. For other subtypes described, more work is needed to determine how robust they are and how to best define them at the molecular level.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Lerner S, McConkey D, Hoadley K, Chan KS, Kim W, Radvanyi F et al. Bladder cancer molecular taxonomy: summary from a consensus meeting. Bladder Cancer. 2016; 2(1): 37-47. DOI 10.3233/BLC-150037ca
- dc.identifier.doi http://dx.doi.org/10.3233/BLC-150037
- dc.identifier.issn 2352-3727
- dc.identifier.uri http://hdl.handle.net/10230/26279
- dc.language.iso engca
- dc.publisher IOS Pressca
- dc.relation.ispartof Bladder Cancer. 2016; 2(1): 37-47
- dc.rights This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licenseca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Bufeta -- Càncerca
- dc.subject.other Genòmicaca
- dc.title Bladder cancer molecular taxonomy: summary from a consensus meetingca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca