Signaling oscillations: Molecular mechanisms and functional roles
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Casani-Galdon, Pablo
- dc.contributor.author García Ojalvo, Jordi
- dc.date.accessioned 2022-11-16T07:37:46Z
- dc.date.available 2022-11-16T07:37:46Z
- dc.date.issued 2022
- dc.description.abstract Mounting evidence shows that oscillatory activity is widespread in cell signaling. Here, we review some of this recent evidence, focusing on both the molecular mechanisms that potentially underlie such dynamical behavior, and the potential advantages that signaling oscillations might have in cell function. The biological processes considered include cellular differentiation and tissue maintenance, intermittent responses in pluripotent stem cells, and collective cell migration during wound healing. With the aid of mathematical modeling, we review recent examples in which delayed negative feedback has been seen to act as a unifying principle that underpins this wide variety of phenomena.
- dc.description.sponsorship We acknowledge financial support from the Spanish Ministry of Science and Innovation and FEDER (grant PGC2018-101251-B-I00), by the “Maria de Maeztu” Programme for Units of Excellence in R&D (grant CEX2018-000792-M), and by the Generalitat de Catalunya (ICREA Academia programme).
- dc.format.mimetype application/pdf
- dc.identifier.citation Casani-Galdon P, Garcia-Ojalvo J. Signaling oscillations: Molecular mechanisms and functional roles. Curr Opin Cell Biol. 2022 Oct;78:102130. DOI: 10.1016/j.ceb.2022.102130
- dc.identifier.doi http://dx.doi.org/10.1016/j.ceb.2022.102130
- dc.identifier.issn 0955-0674
- dc.identifier.uri http://hdl.handle.net/10230/54883
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Curr Opin Cell Biol. 2022 Oct;78:102130
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-101251-B-I00
- dc.rights © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.title Signaling oscillations: Molecular mechanisms and functional roles
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion