Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studies

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• dc.contributor.author Vidal-Palencia, Laura
• dc.contributor.author Font, Cristina
• dc.contributor.author Rebollada-Merino, Agustín
• dc.contributor.author Santpere Baró, Gabriel, 1981-
• dc.contributor.author Andrés Benito, Pol
• dc.contributor.author Ferrer, Isidre
• dc.contributor.author Pumarola, Martí
• dc.date.accessioned 2024-04-25T06:01:25Z
• dc.date.available 2024-04-25T06:01:25Z
• dc.date.issued 2023
• dc.description.abstract Tauopathies are a group of neurodegenerative diseases characterized by the pathological aggregation of hyperphosphorylated tau in neurons and glia. Primary tauopathies are not uncommon in humans but exceptional in other species. We evaluate the clinical, neuropathological, and genetic alterations related to tau pathology in 16 cats aged from 1 to 21 years with different clinical backgrounds. Interestingly, a 10-year-old female cat presented a six-year progressive history of mental status and gait abnormalities. The imaging study revealed generalized cortical atrophy. Due to the poor prognosis, the cat was euthanatized at the age of ten. Neuropathological lesions were characterized by massive neuronal loss with marked spongiosis and associated moderate reactive gliosis in the parietal cortex, being less severe in other areas of the cerebral cortex, and the loss of Purkinje cells of the cerebellum. Immunohistochemical methods revealed a 4R-tauopathy with granular pre-tangles in neurons and coiled bodies in oligodendrocytes. Deposits were recognized with several phospho-site antibodies (4Rtau, tau5, AT8, PFH, tau-P Thr181, tau-P-Ser 262, tau-P Ser 422) and associated with increased granular expression of active tau kinases (p38-P Thr180/Tyr182 and SAPK/JNK-P Thr138/Thr185). The genetic study revealed well-preserved coding regions of MAPT. No similar alterations related to tau pathology were found in the other 15 cats processed in parallel. To our knowledge, this is the first case reporting a primary 4R-tauopathy with severe cerebral and Purkinje cell degeneration in an adult cat with neurological signs starting at a young age.
• dc.description.sponsorship L.V.-P. is supported by an FI predoctoral fellowship (2023 FI-3 00034) from the Generalitat de Catalunya (AGAUR). G.S. is supported by Instituto de Salud Carlos III Spain and European Social Fund grant MS20/00064; grant PID2019-104700GA-I00 funded by /AEI/10.13039/501100011033; grant 202230-30 from Fundació La Marató de TV3; and National Institutes of Health grant R01HG010898-01. I.F. and P.A-B are funded by “la Caixa” Foundation (ID 100010434) under the agreement LCF/PR/ HR19/52160007, HR18–00452.
• dc.format.mimetype application/pdf
• dc.identifier.citation Vidal-Palencia L, Font C, Rebollada-Merino A, Santpere G, Andrés-Benito P, Ferrer I, et al. Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studies. Animals (Basel). 2023 Sep 21;13(18):2985. DOI: 10.3390/ani13182985
• dc.identifier.doi http://dx.doi.org/10.3390/ani13182985
• dc.identifier.issn 2076-2615
• dc.identifier.uri http://hdl.handle.net/10230/59900
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Animals (Basel). 2023 Sep 21;13(18):2985
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-104700GA-I00
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cat
• dc.subject.keyword Neurodegenerative disease
• dc.subject.keyword Tau
• dc.subject.keyword Tauopathy
• dc.subject.keyword Veterinary neuropathology
• dc.title Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studies
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion