Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients

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• dc.contributor.author Sans-de San Nicolás, Lídia
• dc.contributor.author Figueras-Nart, Ignasi
• dc.contributor.author García Jiménez, Irene
• dc.contributor.author Bonfill-Ortí, Montserrat
• dc.contributor.author Guilabert, Antonio
• dc.contributor.author Curto Barredo, Laia
• dc.contributor.author Bertolín Colilla, Marta
• dc.contributor.author Ferran Farrés, Marta
• dc.contributor.author Serra-Baldrich, Esther
• dc.contributor.author Pujol Vallverdú, Ramon Maria
• dc.contributor.author Santamaria-Babí, Luis F.
• dc.date.accessioned 2024-03-05T07:32:26Z
• dc.date.available 2024-03-05T07:32:26Z
• dc.date.issued 2023
• dc.description.abstract Background: The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized. Methods: The response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58) and control subjects (n=11) was evaluated. AD-associated cytokines from culture supernatants, plasma proteins and mRNA expression from cutaneous lesions were assessed and related with the clinical features of the patients. Results: HDM-induced IL-31 production by memory T cells defined two subsets of AD patients according to the presence or absence of IL-31 response. Patients in the IL-31 producing group showed a more inflammatory profile, and increased HDM-specific (sp) and total IgE levels compared to the IL-31 non-producing group. A correlation between IL-31 production and patient's pruritus intensity, plasma CCL27 and periostin was detected. When the same patients were analyzed based on sp IgE and total IgE levels, an increased IL-31 in vitro response, as well as type 2 markers in plasma and cutaneous lesions, was found in patients with sp IgE levels > 100 kUA/L and total IgE levels > 1000 kU/L. The IL-31 response by memory T cells was restricted to the cutaneous lymphocyte-associated antigen (CLA)+ T-cell subset. Conclusion: IgE sensitization to HDM allows stratifying IL-31 production by memory T cells in AD patients and relating it to particular clinical phenotypes of the disease.
• dc.format.mimetype application/pdf
• dc.identifier.citation Sans-de San Nicolàs L, Figueras-Nart I, García-Jiménez I, Bonfill-Ortí M, Guilabert A, Curto-Barredo L, Bertolín-Colilla M, Ferran M, Serra-Baldrich E, Pujol RM, Santamaria-Babí LF. Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients. Front Immunol. 2023 Mar 13;14:1124018. DOI: 10.3389/fimmu.2023.1124018
• dc.identifier.doi http://dx.doi.org/10.3389/fimmu.2023.1124018
• dc.identifier.issn 1664-3224
• dc.identifier.uri http://hdl.handle.net/10230/59322
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Front Immunol. 2023 Mar 13;14:1124018
• dc.rights © 2023 Sans-de San Nicolàs, Figueras-Nart, García-Jiménez, Bonfill-Ortí, Guilabert, Curto-Barredo, Bertolín-Colilla, Ferran, Serra-Baldrich, Pujol and Santamaria-Babí. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword CCL27
• dc.subject.keyword CLA+ memory T cells
• dc.subject.keyword IL-31
• dc.subject.keyword IgE
• dc.subject.keyword Atopic dermatitis
• dc.subject.keyword House dust mite
• dc.subject.keyword Periostin
• dc.subject.keyword Pruritus
• dc.title Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion