Estimated population prevalence of heart failure with reduced ejection fraction in Spain, according to DAPA-HF Study Criteria

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• dc.contributor.author Camps-Vilaró, Anna
• dc.contributor.author Delgado-Jiménez, Juan F.
• dc.contributor.author Farré López, Núria
• dc.contributor.author Tizón-Marcos, Helena
• dc.contributor.author Álvarez-García, Jesus
• dc.contributor.author Cinca, Juan
• dc.contributor.author Dégano, Irene R.
• dc.contributor.author Marrugat de la Iglesia, Jaume
• dc.date.accessioned 2020-10-01T06:28:09Z
• dc.date.available 2020-10-01T06:28:09Z
• dc.date.issued 2020
• dc.description.abstract Heart failure (HF) is one of the main causes of morbidity, mortality, and high healthcare costs. Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, reduced cardiovascular mortality and hospitalization for HF compared to placebo in patients with chronic HF, and reduced ejection fraction (EF) in the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure (DAPA-HF) study. Our aim was to estimate the number of patients with DAPA-HF characteristics in Spain. Our literature review identified epidemiological studies whose objective was to quantify the prevalence of HF and its comorbidities in Spain. We estimated the prevalence of HF with reduced EF, of New York Heart Association (NYHA) functional class II-IV, and with a glomerular filtration rate (GFR) ≥ 30 mL/min/1.73 m². In this population, we analysed the prevalence of diabetes using data from the REDINSCOR (Spanish Network for Heart Failure) registry. Our estimations indicate there are 594,684 patients ≥45 years old with HF in Spain (2.6% of this population age group), of which 52.4%, 84.0%, and 93.9% have reduced EF, are NYHA II-IV, and have a GFR ≥ 30 mL/min/1.73 m², respectively. By our calculations, approximately 245,789 Spanish patients would meet the DAPA-HF patient profile, and therefore could benefit from the protective cardiovascular effects of dapagliflozin.
• dc.format.mimetype application/pdf
• dc.identifier.citation Camps-Vilaró A, Delgado-Jiménez JF, Farré N, Tizón-Marcos H, Álvarez-García J, Cinca J. et al. Estimated population prevalence of heart failure with reduced ejection fraction in Spain, according to DAPA-HF Study Criteria. J Clin Med. 2020 Jul 3; 9(7):2089. DOI: 10.3390/jcm9072089
• dc.identifier.doi http://dx.doi.org/10.3390/jcm9072089
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/45361
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cardiovascular disease
• dc.subject.keyword Cardiovascular therapy
• dc.subject.keyword Dapagliflozin
• dc.subject.keyword Epidemiology
• dc.subject.keyword Heart failure
• dc.subject.keyword Prevalence
• dc.subject.keyword Reduced ejection fraction
• dc.subject.keyword Sodium-glucose cotransporter-2 inhibitor
• dc.title Estimated population prevalence of heart failure with reduced ejection fraction in Spain, according to DAPA-HF Study Criteria
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion