Risk factors associated with major complications after ultrasound-guided percutaneous renal biopsy of native kidneys

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• dc.contributor.author Pombas, Beatriz
• dc.contributor.author Sánchez Parrila, Juan
• dc.contributor.author Radosevic, Aleksandar, 1974-
• dc.contributor.author Gimeno Beltran, Javier
• dc.contributor.author Busto Barrera, Marcos
• dc.contributor.author Barrios Barrera, Clara
• dc.contributor.author Sans Atxer, Laia
• dc.contributor.author Pascual Santos, Julio
• dc.contributor.author Soler, María José
• dc.date.accessioned 2020-06-11T07:14:43Z
• dc.date.available 2020-06-11T07:14:43Z
• dc.date.issued 2020
• dc.description.abstract Introduction: Percutaneous renal biopsy (PRB) of native kidneys is an important tool for diagnosis and management of renal disease. In this study, we analyzed the success, safety, and risk complications of PRB in our center. Methods: A retrospective review of ultrasound-guided PRB done at our institution from January 1998 to December 2017 was performed. Clinical and laboratory data were collected for 661 PRBs. Statistical analysis was performed using the Mann-Whitney U test for continuous variable and chi-square test for categorical variables. Multivariate analysis using logistic regression was performed to assess factors associated with increased risk of complications after PRB. Results: The median age was 56 (42-68) years old, the majority were male (64%) and white (82%). Ten glomeruli were present in 63.5% of PRBs. Overall, the rate of complications was 16.6%, where 15.1% of them were minor complications and 1.5% were major complications. Perinephritic hematoma accounted for the minor complication that occurred most frequently, whereas the need of a blood transfusion was the prevalent for major complications. By multivariate analysis, increased activated partial thromboplastin time (aPTT; OR 1.11, 95% CI 1.035-1.180) and prebiopsy lower hemoglobin (Hgb; OR 1.61, 95% CI 1.086-2.304) were identified as independent risk factors for major complications. In addition, older patients (OR 1.057, 95% CI 1.001-1.117) were identified as an independent risk factor for blood transfusion requirement. Conclusion: The current risk of complications after native PRB is low. Major complications are most common in case of increased aPTT and decreased Hgb baseline level.
• dc.format.mimetype application/pdf
• dc.identifier.citation Pombas B, Rodríguez E, Sánchez J, Radosevic A, Gimeno J, Busto M, et al. Risk factors associated with major complications after ultrasound-guided percutaneous renal biopsy of native kidneys. Kidney Blood Press Res. 2020; 45(1):122-30. DOI: 10.1159/000504544
• dc.identifier.doi http://dx.doi.org/10.1159/000504544
• dc.identifier.issn 1420-4096
• dc.identifier.uri http://hdl.handle.net/10230/44953
• dc.language.iso eng
• dc.publisher Karger (S. Karger AG)
• dc.rights This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). https://creativecommons.org/licenses/by/4.0/. Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Bleeding
• dc.subject.keyword Complications risk
• dc.subject.keyword Kidney disease
• dc.subject.keyword Renal biopsy
• dc.title Risk factors associated with major complications after ultrasound-guided percutaneous renal biopsy of native kidneys
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion