Feasibility and short-term outcomes in liver-first approach: A spanish snapshot study (the RENACI Project)
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Serradilla Martín, Mario
- dc.contributor.author Burdío Pinilla, Fernando
- dc.contributor.author Ielpo, Benedetto
- dc.contributor.author Ramia, José Manuel
- dc.date.accessioned 2025-03-11T07:14:57Z
- dc.date.available 2025-03-11T07:14:57Z
- dc.date.issued 2024
- dc.description.abstract (1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11.1%) using the liver-first approach, 63 (42.0%) in hospitals performing <50 hepatectomies/year. The proportion of patients as ASA III was significantly higher in centers performing ≥50 hepatectomies/year (difference: 18.9%; p = 0.0213). In 81.1% of the cases, the primary tumor was in the rectum or sigmoid colon. In total, 40% of the patients underwent major hepatectomies. The surgical approach was open surgery in 87 (58.0%) patients. Resection margins were R0 in 78.5% of the patients. In total, 40 (26.7%) patients had complications after the liver resection and 36 (27.3%) had complications after the primary resection. One-hundred and thirty-two (89.3%) patients completed the therapeutic regime. (4) Conclusions: There were no differences in the surgical outcomes between the centers performing <50 and ≥50 hepatectomies/year. Further analysis evaluating factors associated with clinical outcomes and determining the best candidates for this approach will be subsequently conducted.
- dc.format.mimetype application/pdf
- dc.identifier.citation Serradilla-Martín M, Villodre C, Falgueras-Verdaguer L, Zambudio-Carroll N, Castell-Gómez JT, Blas-Laina JL, et al. Feasibility and short-term outcomes in liver-first approach: A spanish snapshot study (the RENACI Project). Cancers (Basel). 2024 Apr 26;16(9):1676. DOI: 10.3390/cancers16091676
- dc.identifier.doi http://dx.doi.org/10.3390/cancers16091676
- dc.identifier.issn 2072-6694
- dc.identifier.uri http://hdl.handle.net/10230/69907
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Cancers (Basel). 2024 Apr 26;16(9):1676
- dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Colorectal cancer
- dc.subject.keyword Disease-free survival
- dc.subject.keyword Liver metastases
- dc.subject.keyword Liver-first approach
- dc.title Feasibility and short-term outcomes in liver-first approach: A spanish snapshot study (the RENACI Project)
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion