Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial

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  • dc.contributor.author Martí, Amelia
  • dc.contributor.author Fernández de la Puente, María
  • dc.contributor.author Canudas i Puig, Sílvia
  • dc.contributor.author Zalba, Guillermo
  • dc.contributor.author Razquin, Cristina
  • dc.contributor.author Valle-Hita, Cristina
  • dc.contributor.author Fitó Colomer, Montserrat
  • dc.contributor.author Martínez-González, Miguel Ángel, 1957-
  • dc.contributor.author García-Calzón, Sonia
  • dc.contributor.author Salas Salvadó, Jordi
  • dc.date.accessioned 2024-05-06T05:46:06Z
  • dc.date.available 2024-05-06T05:46:06Z
  • dc.date.issued 2023
  • dc.description.abstract Background & aims: Short telomeres have been observed in chronic disease patients. Identifying environmental and lifestyle factors that could reduce telomere attrition is crucial for disease prevention. The aim of this work was to determine whether weight-loss induced by an energy-reduced Mediterranean diet (erMedDiet) and physical activity (PA) could modify telomere length (TL). Methods: In 317 randomized non-smoker participants (mean age, 65.8 ± 4.98 years) with metabolic syndrome from two "Prevención con Dieta Mediterránea-Plus" (PREDIMED-Plus) trial centers, we evaluated MedDiet adherence, PA, anthropometric variables and TL at baseline and after a 3-year intervention using an intensive lifestyle program (IG) with an erMedDiet and PA or an unrestricted MedDiet without PA promotion (CG). Results: Participants in the IG displayed greater 3-year weight reductions (-3.7 ± 4 kg, P < 0.001) compared to those in the CG. No differences in TL changes between groups were observed in the cohort as a whole. However, an interaction was observed between the intervention group and sex for TL changes (pinteraction = 0.039). Women in the IG showed an increase in TL after 3-y (+0.25 ± 0.9, relative units) compared to women in the CG (-0.07 ± 1.0) (pANCOVA = 0.036), whereas no differences between groups were observed in men. Women in the IG had a lower risk of telomere shortening after the intervention (OR = 0.17, 95%CI: 0.05-0.64, p = 0.008) compared to women in the CG. Conclusions: A 3-year lifestyle intervention based on an erMedDiet and PA slowed telomere shortening in women but not in men. Trial registration: ISRCTN, ISRCTN89898870. Registered 24 July 2014- Retrospectively registered, https://www.isrctn.com/ISRCTN89898870.
  • dc.description.sponsorship The authors especially thank the PREDIMED-Plus participants for the enthusiastic collaboration, the PREDIMED-Plus personnel for outstanding support, and the personnel of all associated primary care centers for the exceptional effort. CIBEROBN, CIBERESP, and CIBERDEM are initiatives of Instituto de Salud Carlos III (ISCIII), Madrid, Spain. The authors also thank the PREDIMED-Plus Biobank Network as a part of the National Biobank Platform of the ISCIII for storing and managing the PREDIMED-Plus biological samples. We also thank the INSA-UB Maria de Maeztu Unit of Excellence (Grant CEX2021-001234-M) funded by MICIN/AEI/FEDER, UE. The technical assistance of Veronica Ciaurriz and Maria Martinez is fully acknowledged.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Marti A, Fernández de la Puente M, Canudas S, Zalba G, Razquin C, Valle-Hita C, et al. Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial. Clin Nutr. 2023 Sep;42(9):1581-7. DOI: 10.1016/j.clnu.2023.06.030
  • dc.identifier.doi http://dx.doi.org/10.1016/j.clnu.2023.06.030
  • dc.identifier.issn 0261-5614
  • dc.identifier.uri http://hdl.handle.net/10230/60018
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Clin Nutr. 2023 Sep;42(9):1581-7
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/CEX2021-001234-M
  • dc.rights © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Calorie restriction
  • dc.subject.keyword Mediterranean diet
  • dc.subject.keyword Physical activity
  • dc.subject.keyword Randomized controlled trial
  • dc.subject.keyword Telomere length
  • dc.title Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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