Genome-wide data from the Bubi of Bioko Island clarifies the Atlantic fringe of the Bantu dispersal

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  • dc.contributor.author Gelabert Xirinachs, Pere, 1991-
  • dc.contributor.author Ferrando-Bernal, Manuel, 1990-
  • dc.contributor.author de Dios, Toni
  • dc.contributor.author Mattorre, Benedetta
  • dc.contributor.author Campoy, Elena
  • dc.contributor.author Gorostiza, Amaya
  • dc.contributor.author Patin, Etienne
  • dc.contributor.author González Martín, Antonio
  • dc.contributor.author Lalueza Fox, Carles, 1965-
  • dc.date.accessioned 2020-05-22T07:34:34Z
  • dc.date.available 2020-05-22T07:34:34Z
  • dc.date.issued 2019
  • dc.description.abstract Background: Bioko is one of the few islands that exist around Africa, the most genetically diverse continent on the planet. The native Bantu-speaking inhabitants of Bioko, the Bubi, are believed to have colonized the island about 2000 years ago. Here, we sequenced the genome of thirteen Bubi individuals at high coverage and analysed their sequences in comparison to mainland populations from the Gulf of Guinea. Results: We found that, genetically, the closest mainland population to the Bubi are Bantu-speaking groups from Angola instead the geographically closer groups from Cameroon. The Bubi possess a lower proportion of rainforest hunter-gatherer (RHG) ancestry than most other Bantu-speaking groups. However, their RHG component most likely came from the same source and could have reached them by gene flow from the mainland after island settlement. By studying identity by descent (IBD) genomic blocks and runs of homozygosity (ROHs), we found evidence for a significant level of genetic isolation among the Bubi, isolation that can be attributed to the island effect. Additionally, as this population is known to have one of the highest malaria incidence rates in the world we analysed their genome for malaria-resistant alleles. However, we were unable to detect any specific selective sweeps related to this disease. Conclusions: By describing their dispersal to the Atlantic islands, the genomic characterization of the Bubi contributes to the understanding of the margins of the massive Bantu migration that shaped all Sub-Saharan African populations.
  • dc.description.sponsorship This research was supported by a grant from FEDER and Ministry of Economy and Competitiveness (BFU2015–64699-P) of Spain to C.L-F. CLF is supported by Obra Social "La Caixa" and Secretaria d’Universitats i Recerca Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Gelabert P, Ferrando-Bernal M, de-Dios T, Mattorre B, Campoy E, Gorostiza A, Patin E, González-Martín A, Lalueza-Fox C. Genome-wide data from the Bubi of Bioko Island clarifies the Atlantic fringe of the Bantu dispersal. BMC Genomics. 2019; 20(1):179. DOI: 10.1186/s12864-019-5529-0
  • dc.identifier.doi http://dx.doi.org/10.1186/s12864-019-5529-0
  • dc.identifier.issn 1471-2164
  • dc.identifier.uri http://hdl.handle.net/10230/44645
  • dc.language.iso eng
  • dc.publisher BioMed Central
  • dc.relation.ispartof BMC Genomics. 2019; 20(1):179
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015–64699-P
  • dc.rights © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Bantu-speaking groups
  • dc.subject.keyword Bioko Island
  • dc.subject.keyword Bubi
  • dc.subject.keyword Isolation
  • dc.subject.keyword Population genetics
  • dc.title Genome-wide data from the Bubi of Bioko Island clarifies the Atlantic fringe of the Bantu dispersal
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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