Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registry
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- dc.contributor.author Franco, Antonio
- dc.contributor.author Moreso, Francesc
- dc.contributor.author Solà Porta, Eulàlia
- dc.contributor.author Beneyto, Maria Isabel
- dc.contributor.author Esforzado, Núria
- dc.contributor.author González-Roncero, Francisco
- dc.contributor.author Sancho-Calabuig, Asunción
- dc.contributor.author Melilli, Edoardo
- dc.contributor.author Ruiz San Millán, Juan Carlos
- dc.contributor.author Galeano, Cristina
- dc.contributor.author Renal Transplantation with HCV Positive Donors Spanish Study Group
- dc.date.accessioned 2024-04-29T07:21:21Z
- dc.date.available 2024-04-29T07:21:21Z
- dc.date.issued 2023
- dc.description.abstract Historically, donor infection with hepatitis-C virus (HCV) has been a barrier to kidney transplantation. However, in recent years, it has been reported that HCV positive kidney donors transplanted into HCV negative recipients offer acceptable mid-term results. However, acceptance of HCV donors, especially viremic, has not broadened in the clinical practice. This is an observational, multicenter, retrospective study including kidney transplants from HCV positive donors into negative recipients reported to the Spanish group from 2013 to 2021. Recipients from viremic donors received peri-transplant treatment with direct antiviral agents (DAA) for 8–12 weeks. We included 75 recipients from 44 HCV non-viremic donors and 41 from 25 HCV viremic donors. Primary non function, delayed graft function, acute rejection rate, renal function at the end of follow up, and patient and graft survival were not different between groups. Viral replication was not detected in recipients from non-viremic donors. Recipient treatment with DAA started pre-transplant avoids (n = 21) or attenuates (n = 5) viral replication but leads to non-different outcomes to post-transplant treatment with DAA (n = 15). HCV seroconversion was more frequent in recipients from viremic donors (73% vs. 16%, p < 0.001). One recipient of a viremic donor died due to hepatocellular carcinoma at 38 months. Donor HCV viremia seems not to be a risk factor for kidney transplant recipients receiving peri-transplant DAA, but continuous surveillance should be advised.
- dc.format.mimetype application/pdf
- dc.identifier.citation Franco A, Moreso F, Solà-Porta E, Beneyto I, Esforzado N, Gonzalez-Roncero F, et al. Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registry. J Clin Med. 2023 Feb 23;12(5):1773. DOI: 10.3390/jcm12051773
- dc.identifier.doi http://dx.doi.org/10.3390/jcm12051773
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/59928
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Clin Med. 2023 Feb 23;12(5):1773
- dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Kidney transplantation
- dc.subject.keyword Hepatitis C virus
- dc.subject.keyword Viremic donor
- dc.subject.keyword Graft outcome
- dc.subject.keyword Hepatocellular carcinoma
- dc.title Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registry
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion