Association of ambient and household air pollution with lung function in young adults in an peri-urban area of South-India: A cross-sectional study

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• dc.contributor.author Ranzani, Otavio
• dc.contributor.author Bhogadi, Santhi
• dc.contributor.author Milà, Carles
• dc.contributor.author Kulkarni, Bharati
• dc.contributor.author Balakrishnan, Kalpana
• dc.contributor.author Sambandam, Sankar
• dc.contributor.author García Aymerich, Judith
• dc.contributor.author Marshall, Julian D.
• dc.contributor.author Kinra, Sanjay
• dc.contributor.author Tonne, Cathryn
• dc.date.accessioned 2022-11-24T07:01:06Z
• dc.date.available 2022-11-24T07:01:06Z
• dc.date.issued 2022
• dc.description.abstract Objective: Although there is evidence for the association between air pollution and decreased lung function in children, evidence for adolescents and young adults is scarce. For a peri-urban area in India, we evaluated the association of ambient PM2.5 and household air pollution with lung function for young adults who had recently attained their expected maximum lung function. Methods: We measured, using a standardized protocol, forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) in participants aged 20-26 years from the third follow-up of the population-based APCAPCS cohort (2010-2012) in 28 Indian villages. We estimated annual average PM2.5outdoors at residence using land-use regression. Biomass cooking fuel (a proxy for levels of household air pollution) was self-reported. We fitted a within-between linear-mixed model with random intercepts by village, adjusting for potential confounders. Results: We evaluated 1,044 participants with mean age of 22.8 (SD = 1) years (range 20-26 years); 327 participants (31%) were female. Only males reported use of tobacco smoking (9% of all participants, 13% of males). The mean ambient PM2.5 exposure was 32.9 (SD = 2.8) µg/m3; 76% reported use of biomass as cooking fuel. The adjusted association between 1 µg/m3 increase in PM2.5 was -27 ml (95% CI, -89 to 34) for FEV1 and -5 ml (95% CI, -93 to 76) for FVC. The adjusted association between use of biomass was -112 ml (95% CI, -211 to -13) for FEV1 and -142 ml (95% CI, -285 to 0) for FVC. The adjusted association was of greater magnitude for those with unvented stove (-158 ml, 95% CI, -279 to -36 for FEV1 and -211 ml, 95% CI, -386 to -36 for FVC). Conclusions: We observed negative associations between ambient PM2.5 and household air pollution and lung function in young adults who had recently attained their maximum lung function.
• dc.description.sponsorship The research leading to these results received funding from the European Research Council under ERC Grant Agreement number 336167 for the CHAI Project. The third wave of data collection and village socio-demographic surveys for the APCAPS study were funded by the Wellcome Trust (Grant: 084674/Z). OTR is funded by a Sara Borrell fellowship (CD19/00110) from the Instituto de Salud Carlos III. CT was funded through a Ramón y Cajal fellowship (RYC-2015-17402) awarded by the Spanish Ministry of Economy and Competitiveness. We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ranzani OT, Bhogadi S, Milà C, Kulkarni B, Balakrishnan K, Sambandam S, Garcia-Aymerich J, Marshall JD, Kinra S, Tonne C. Association of ambient and household air pollution with lung function in young adults in an peri-urban area of South-India: A cross-sectional study. Environ Int. 2022 Jul;165:107290. DOI: 10.1016/j.envint.2022.107290
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2022.107290
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/54988
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Int. 2022 Jul;165:107290
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/336167
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/RYC-2015-17402
• dc.rights © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Air pollution
• dc.subject.keyword Household air pollution
• dc.subject.keyword India
• dc.subject.keyword Lung function
• dc.subject.keyword Particulate matter
• dc.title Association of ambient and household air pollution with lung function in young adults in an peri-urban area of South-India: A cross-sectional study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion