Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions

Guasch Ferré, Marta; Zheng, Yan; Ruiz-Canela, Miguel; Martínez-González, Miguel Ángel, 1957-; Corella, Dolores; Estruch, Ramón; Ros, Emilio; Fitó Colomer, Montserrat; Dennis, Courtney; Morales-Gil, Isabel M.; Arós, Fernando; Fiol, Miquel; Lapetra, José; Serra-Majem, Luis; Hu, Frank B.; Salas-Salvadó, Jordi; Hruby, Adela; Clish, Clary B.

Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions

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dc.contributor.author Guasch Ferré, Martaca
dc.contributor.author Zheng, Yanca
dc.contributor.author Ruiz-Canela, Miguelca
dc.contributor.author Martínez-González, Miguel Ángel, 1957-ca
dc.contributor.author Corella, Doloresca
dc.contributor.author Estruch, Ramónca
dc.contributor.author Ros, Emilioca
dc.contributor.author Fitó Colomer, Montserratca
dc.contributor.author Dennis, Courtneyca
dc.contributor.author Morales-Gil, Isabel M.ca
dc.contributor.author Arós, Fernandoca
dc.contributor.author Fiol, Miquelca
dc.contributor.author Lapetra, Joséca
dc.contributor.author Serra-Majem, Luisca
dc.contributor.author Hu, Frank B.ca
dc.contributor.author Salas-Salvadó, Jordica
dc.contributor.author Hruby, Adelaca
dc.contributor.author Clish, Clary B.ca
dc.date.accessioned 2017-11-15T08:40:39Z
dc.date.available 2017-11-15T08:40:39Z
dc.date.issued 2017
dc.description.abstract BACKGROUND: Previous studies have suggested that metabolite profiles of elevated acylcarnitines were associated with increased risk of cardiovascular disease (CVD) in populations with established coronary disease. However, to our knowledge, this association has not been evaluated in the context of primary cardiovascular prevention. OBJECTIVES: We evaluated the association between 28 plasma acylcarnitine species and risk of incident CVD and the potential modifying effect of Mediterranean diet (MedDiet) interventions. DESIGN: We measured plasma acylcarnitines with the use of high-throughput liquid chromatography-tandem mass spectrometry at baseline and after 1 y of follow-up, both individually and classified into short-, medium-, or long-chain scores, in a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED) study, which is a randomized Mediterranean dietary intervention for primary cardiovascular prevention. A randomly selected subcohort (n = 751) and all available incident CVD cases (n = 229) after 4.8 y of follow-up were included in the current study. RESULTS: After adjustment for age, sex, body mass index, and other CVD risk factors, participants in the highest quartile of baseline short- and medium-chain acylcarnitines had a higher risk of CVD than did participants in the lowest quartile [HRs: 1.80 (95% CI: 1.11, 2.91; P-trend 0.01) and 1.55 (95% CI: 1.01, 2.48; P-trend = 0.04), respectively]. Increased short-chain acylcarnitines after 1 y were associated with higher risks of total CVD and stroke. Participants with higher baseline concentrations of short-, medium-, and long-chain acylcarnitines who were randomly assigned to the control group had a higher risk of CVD than did subjects with lower concentrations of acylcarnitines who were assigned to the MedDiet group. CONCLUSIONS: Our data support the conclusion that metabolite profiles characterized by elevated concentrations of acylcarnitines are independently associated with risks of total CVD and stroke alone in participants at high risk of CVD. MedDiet interventions may mitigate the adverse associations shown between higher concentrations of acylcarnitines and CVD.
dc.description.sponsorship The Prevención con Dieta Mediterránea (PREDIMED) trial was supported by the official funding agency for biomedical research of the Spanish government, the Instituto de Salud Carlos III, through grants provided to research networks specifically developed for the trial [grant RTIC G03/140 (to RE); grant RTIC RD 06/0045 (to MAM-G)] and through the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición and by grants from Centro Nacional de Investigaciones Cardiovasculares (grant CNIC 06/2007), the Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional (grants PI04–2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, I07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505, and PI13/00462), the Ministerio de Ciencia e Innovación (grants AGL-2009–13906-C02 and AGL2010–22319-C03), the Fundación Mapfre 2010, Consejería de Salud de la Junta de Andalucía (grant PI0105/2007), the Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana (grants ACOMP06109, GVA-COMP2010–181, GVACOMP2011–151, CS2010-AP-111, and CS2011-AP-042), and the Regional Government of Navarra (grant P27/2011).
dc.format.mimetype application/pdfca
dc.identifier.citation Guasch-Ferré M, Zheng Y, Ruiz-Canela M, Hruby A, Martínez-González MA, Clish CB. Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions. Am J Clin Nutr. 2016 Jun;103(6):1408-16. DOI: 10.3945/ajcn.116.130492
dc.identifier.doi http://dx.doi.org/10.3945/ajcn.116.130492
dc.identifier.issn 0002-9165
dc.identifier.uri http://hdl.handle.net/10230/33227
dc.language.iso eng
dc.publisher American Society for Nutritionca
dc.relation.ispartof The American Journal of Clinical Nutrition. 2016 Jun;103(6):1408-16
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.keyword Mediterranean diet
dc.subject.keyword Acylcarnitines
dc.subject.keyword Cardiovascular disease
dc.subject.keyword Metabolomics
dc.subject.other Dieta -- Mediterrània, Regió de la
dc.subject.other Cor -- Malalties
dc.title Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventionsca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/acceptedVersion

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