Scientific competency questions as the basis for semantically enriched open pharmacological space development
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- dc.contributor.author Azzaoui, Kamalca
- dc.contributor.author Jacoby, Edgarca
- dc.contributor.author Senger, Stefanca
- dc.contributor.author Cuadrado Rodríguez, Emilianoca
- dc.contributor.author Loza, Mabelca
- dc.contributor.author Zdrazil, Barbaraca
- dc.contributor.author Pinto, Martaca
- dc.contributor.author Williams, Antony J.ca
- dc.contributor.author Torre, Victor de laca
- dc.contributor.author Mestres i López, Jordica
- dc.contributor.author Pastor Maeso, Manuelca
- dc.contributor.author Taboureau, Olivierca
- dc.contributor.author Rarey, Matthiasca
- dc.contributor.author Chichester, Christineca
- dc.contributor.author Pettifer, Steveca
- dc.contributor.author Blomberg, Niklasca
- dc.contributor.author Harland, Leeca
- dc.contributor.author Williams-Jones, Brynca
- dc.contributor.author Ecker, Gerhard F.ca
- dc.date.accessioned 2015-11-25T15:43:47Z
- dc.date.available 2015-11-25T15:43:47Z
- dc.date.issued 2013
- dc.description.abstract Molecular information systems play an important part in modern data-driven drug discovery. They do not only support decision making but also enable new discoveries via association and inference. In this review, we outline the scientific requirements identified by the Innovative Medicines Initiative (IMI) Open PHACTS consortium for the design of an open pharmacological space (OPS) information system. The focus of this work is the integration of compound-target-pathway-disease/phenotype data for public and industrial drug discovery research. Typical scientific competency questions provided by the consortium members will be analyzed based on the underlying data concepts and associations needed to answer the questions. Publicly available data sources used to target these questions as well as the need for and potential of semantic web-based technology will be presented.ca
- dc.description.sponsorship The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. [115191], resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013) and inkind contribution of EFPIA companies.en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Azzaoui K, Jacoby E, Senger S, Rodríguez EC, Loza M, Zdrazil B, et al. Scientific competency questions as the basis for semantically enriched open pharmacological space development. Drug discovery today. 2013;18(17-18):843-52. DOI: 10.1016/j.drudis.2013.05.008ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.drudis.2013.05.008
- dc.identifier.issn 1359-6446
- dc.identifier.uri http://hdl.handle.net/10230/25218
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Drug discovery today. 2013;18(17-18):843-52
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/115191
- dc.rights © 2013 Elsevier Ltd. All rights reserved.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Medicaments -- Desenvolupament
- dc.subject.other Farmàcia -- Investigació
- dc.subject.other Mineria de dades
- dc.title Scientific competency questions as the basis for semantically enriched open pharmacological space developmentca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca