Maternal ferritin levels during pregnancy and ADHD symptoms in 4-year-old children: results from the INMA-INfancia y Medio Ambiente (environment and childhood) prospective birth cohort study

Santa Marina, Loreto; Lertxundi, Nerea; Andiarena, Ainara; Irizar, Amaia; Sunyer Deu, Jordi; Molinuevo, Amaia; Llop, Sabrina; Júlvez Calvo, Jordi; Beneito, Andrea; Ibarluzea, Jesús; Imaz, Liher; Ferrin, Maite

Maternal ferritin levels during pregnancy and ADHD symptoms in 4-year-old children: results from the INMA-INfancia y Medio Ambiente (environment and childhood) prospective birth cohort study

Mostra el registre complet Registre parcial de l'ítem

dc.contributor.author Santa Marina, Loreto
dc.contributor.author Lertxundi, Nerea
dc.contributor.author Andiarena, Ainara
dc.contributor.author Irizar, Amaia
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Molinuevo, Amaia
dc.contributor.author Llop, Sabrina
dc.contributor.author Júlvez Calvo, Jordi
dc.contributor.author Beneito, Andrea
dc.contributor.author Ibarluzea, Jesús
dc.contributor.author Imaz, Liher
dc.contributor.author Ferrin, Maite
dc.date.accessioned 2021-07-16T07:13:11Z
dc.date.available 2021-07-16T07:13:11Z
dc.date.issued 2020
dc.description.abstract Ferritin status during prenatal brain development may influence the risk of attention deficit and hyperactivity disorder (ADHD) symptoms in childhood. We investigated the association of maternal ferritin in pregnancy and ADHD-like symptoms in offspring. A total of 1095 mother-child pairs from three birth cohorts of the INMA Project (Spain) were studied. Maternal plasma ferritin in pregnancy was measured at 11.57 weeks of gestation. Children's ADHD-like symptoms at ages 4-5 years were assessed using the ADHD Rating Scale-IV. The count model of the zero-inflated Poisson regression model showed a significant inverse association between ferritin (continuous variable) and inattention, β = -0.19 (-0.32, -0.07), for boys. Comparing ferritin level by tertiles, significant differences were observed between the first tertile ([1.98, 20.92]) and the second ([20.92, 38.79]) and third tertiles ([38.79, 216.5]) (mg/L).The number of symptoms was lower for those in the third tertile, β = -0.3 (-0.55, -0.5), and for those in the second one, β = -0.37 (-0.6, -0.14). The model stratification by sex also showed this inverse association for boys only, β = -0.21 (-0.34, -0.08). No associations were found between ferritin level and hyperactivity or total ADHD symptoms. High ferritin levels during pregnancy show a protective association with child inattentive-type ADHD symptoms.
dc.description.sponsorship Gipuzkoa: This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090 and FIS-PI13/02187), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069 and 2013111089) and the Provincial Government of Gipuzkoa (DFG06/002 and DFG08/001). Sabadell: This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; and PI081151 including support from the European Regional Development Fund (ERDF), Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430). ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. Valencia: This study was funded by grants from the European Union (FP7-ENV-2011, grant number: 282957 and HEALTH.2010.2.4.5-1); Spain (ISCIII: G03/176; FIS-ERDF: PI11/01007, PI11/02591, PI11/02038, PI12/00610, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, and PI17/00663; Miguel Servet-European Regional Development Fund CP11/00178, CP15/00025, and MSII16/00051); Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249); and the Alicia Koplowitz Foundation (2017); Instituto de Salud Carlos III through the projects “CP14/00108 and PI16/00261” (Co-funded by European Regional Development Fund “A way to make Europe”). Jordi Julvez holds the Miguel Servet-II contract (CPII19/00015) awarded by the Instituto de Salud Carlos III (co-funded by the European Social Fund “Investing in your future”).
dc.format.mimetype application/pdf
dc.identifier.citation Santa-Marina L, Lertxundi N, Andiarena A, Irizar A, Sunyer J, Molinuevo A, et al. Maternal ferritin levels during pregnancy and ADHD symptoms in 4-year-old children: results from the INMA-INfancia y Medio Ambiente (environment and childhood) prospective birth cohort study. Int J Environ Res Public Health. 2020 Oct 22; 17(21): 7704. DOI: 10.3390/ijerph17217704
dc.identifier.doi http://dx.doi.org/10.3390/ijerph17217704
dc.identifier.issn 1660-4601
dc.identifier.uri http://hdl.handle.net/10230/48204
dc.language.iso eng
dc.publisher MDPI
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword ADHD symptoms
dc.subject.keyword Childhood
dc.subject.keyword Ferritin status
dc.subject.keyword Pregnancy
dc.title Maternal ferritin levels during pregnancy and ADHD symptoms in 4-year-old children: results from the INMA-INfancia y Medio Ambiente (environment and childhood) prospective birth cohort study
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Hospital del Mar Research Institute)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)