p53 regulates the mevalonate pathway in human glioblastoma multiforme
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- dc.contributor.author Laezza, Chiaraca
- dc.contributor.author D'Alessandro, Albaca
- dc.contributor.author Di Croce, Lucianoca
- dc.contributor.author Picardi, Paolaca
- dc.contributor.author Ciaglia, Elenaca
- dc.contributor.author Pisanti, Simonaca
- dc.contributor.author Malfitano, Anna Mariaca
- dc.contributor.author Comegna, Marikaca
- dc.contributor.author Faraonio, Raffaellaca
- dc.contributor.author Gazzerro, Patriziaca
- dc.contributor.author Bifulco, Maurizioca
- dc.date.accessioned 2015-11-09T16:21:00Z
- dc.date.available 2015-11-09T16:21:00Z
- dc.date.issued 2015
- dc.description.abstract The mevalonate (MVA) pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, we provided evidence that p53 induces the expression of a group of enzymes of the MVA pathway including 3′-hydroxy-3′- methylglutaryl-coenzyme A reductase, MVA kinase, farnesyl diphosphate synthase and farnesyl diphosphate farnesyl transferase 1, in the human glioblastoma multiforme cell line, U343 cells, and in normal human astrocytes, NHAs. Genetic and pharmacologic perturbation of p53 directly influences the expression of these genes. Furthermore, p53 is recruited to the gene promoters in designated p53-responsive elements, thereby increasing their transcription. Such effect was abolished by site-directed mutagenesis in the p53-responsive element of promoter of the genes. These findings highlight another aspect of p53 functions unrelated to tumor suppression and suggest p53 as a novel regulator of the MVA pathway providing insight into the role of this pathway in cancer progression.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Laezza C, D'Alessandro A, Di Croce L, Picardi P, Ciaglia E, Pisanti S et al. p53 regulates the mevalonate pathway in human glioblastoma multiforme. Cell Death and Disease. 2015;6:e1909. DOI: 10.1038/cddis.2015.279ca
- dc.identifier.doi http://dx.doi.org/10.1038/cddis.2015.279
- dc.identifier.issn 2041-4889
- dc.identifier.uri http://hdl.handle.net/10230/25025
- dc.language.iso engca
- dc.publisher Nature Publishing Groupca
- dc.relation.ispartof Cell Death and Disease. 2015;6:e1909
- dc.rights Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Gen p53ca
- dc.title p53 regulates the mevalonate pathway in human glioblastoma multiformeen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca