Targeting human urinary metabolome by LC-MS/MS: a review

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• dc.contributor.author Rodríguez-Morató, Jose, 1987-
• dc.contributor.author Pozo Mendoza, Óscar J., 1975-
• dc.contributor.author Marcos del Águila, Josep, 1971-
• dc.date.accessioned 2022-03-23T07:28:24Z
• dc.date.available 2022-03-23T07:28:24Z
• dc.date.issued 2018
• dc.description.abstract Urine is a biological matrix that contains hundreds of metabolic end products which constitute the urinary metabolome. The development and advances on LC-MS/MS have revolutionized the analytical study of biomolecules by enabling their accurate identification and quantification in an unprecedented manner. Nowadays, LC-MS/MS is helping to unveil the complexity of urine metabolome, and the results obtained have multiple biomedical applications. This review focuses on the targeted LC-MS/MS analysis of the urine metabolome. In the first part, we describe general considerations (from sample collection to quantitation) required for a proper targeted metabolic analysis. In the second part, we address the urinary analysis and recent applications of four relevant families: amino acids, catecholamines, lipids and steroids.
• dc.description.sponsorship J Rodríguez-Morató acknowledges funding from the EU's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 712949 (TECNIOspring PLUS) and from the Agency for Business Competitiveness of the Government of Catalonia. Spanish Health National System is acknowledged for O J Pozo contract (CPII16/00027). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
• dc.format.mimetype application/pdf
• dc.identifier.citation Rodríguez-Morató J, Pozo ÓJ, Marcos J. Targeting human urinary metabolome by LC-MS/MS: a review. Bioanalysis. 2018 Apr 1;10(7):489-516. DOI: 10.4155/bio-2017-0285
• dc.identifier.doi http://dx.doi.org/10.4155/bio-2017-0285
• dc.identifier.issn 1757-6180
• dc.identifier.uri http://hdl.handle.net/10230/52752
• dc.language.iso eng
• dc.publisher Future Science
• dc.relation.ispartof Bioanalysis. 2018 Apr 1;10(7):489-516
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/712949
• dc.rights This is the author's final version of the following article: Rodríguez-Morató J, Pozo ÓJ, Marcos J. Targeting human urinary metabolome by LC-MS/MS: a review. Bioanalysis. 2018 Apr 1;10(7):489-516. DOI: 10.4155/bio-2017-0285, which has been published in final form at http://dx.doi.org/10.4155/bio-2017-0285.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword LC–MS/MS
• dc.subject.keyword Amino acids
• dc.subject.keyword Lipids
• dc.subject.keyword Neurotransmitters
• dc.subject.keyword Quantitation
• dc.subject.keyword Steroids
• dc.subject.keyword Targeted metabolomics
• dc.subject.keyword Untargeted metabolomics
• dc.subject.keyword Urine
• dc.title Targeting human urinary metabolome by LC-MS/MS: a review
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion