MCPIP1 RNase is aberrantly distributed in psoriatic epidermis and rapidly induced by IL-17A.
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Ruiz-Romeu, Esterca
- dc.contributor.author Ferran Farrés, Martaca
- dc.contributor.author Giménez Arnau, Anna Mariaca
- dc.contributor.author Bugara, Beataca
- dc.contributor.author Lipert, Barbaraca
- dc.contributor.author Jura, Jolantaca
- dc.contributor.author Florencia, Edwin F.ca
- dc.contributor.author Prens, Errol P.ca
- dc.contributor.author Celada, Antonioca
- dc.contributor.author Pujol Vallverdú, Ramon Mariaca
- dc.contributor.author Santamaría-Babí, Luis Franciscoca
- dc.date.accessioned 2016-09-29T08:35:21Z
- dc.date.issued 2016
- dc.description.abstract ZC3H12A, which encodes the RNase monocyte chemotactic protein-induced protein 1 (MCPIP1), is up-regulated in psoriatic skin and reduced to normal levels after clinical treatments with anti-IL-17A/IL-17R neutralizing antibodies. In IL-17A-stimulated keratinocytes, MCPIP1 is rapidly increased at the transcript and protein levels. Also, IL-17A was found to be the main inducer of ZC3H12A expression in keratinocytes treated with supernatants derived from a Streptococcus pyogenes-activated psoriatic ex vivo model based on the co-culture of psoriatic cutaneous lymphocyte-associated antigen (CLA(+)) T cells and lesional epidermal cells. Moreover, MCPIP1 was aberrantly distributed in the suprabasal layers of psoriatic epidermis. In psoriatic samples, IL-17A-stimulated epidermal cell suspensions showed an increased MCPIP1 expression, especially in the mid-differentiated cellular compartment. The knockdown of ZC3H12A showed that this RNase participates in the regulation of the mRNAs present in suprabasal differentiated keratinocytes. Furthermore, JAK/STAT3 inhibition prevented the IL-17A-dependent induction of MCPIP1. In the mouse model of imiquimod-induced psoriasis, Zc3h12a expression was abrogated in Il17ra(-/-) mice. These results support the notion that IL-17A-mediated induction of MCPIP1 is involved in the regulation of local altered gene expression in suprabasal epidermal layers in psoriasis.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Ruiz-Romeu E, Ferran M, Giménez-Arnau A, Bugara B, Lipert B, Jura J. et al. MCPIP1 RNase is aberrantly distributed in psoriatic epidermis and rapidly induced by IL-17A. J Invest Dermatol. 2016 Aug;136(8):1599-607. doi: 10.1016/j.jid.2016.04.030ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.jid.2016.04.030
- dc.identifier.issn 0022-202X
- dc.identifier.uri http://hdl.handle.net/10230/27319
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Journal of Investigative Dermatology. 2016 Aug;136(8):1599-607
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.jid.2016.04.030ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Dermatologiaca
- dc.subject.other Psoriasica
- dc.title MCPIP1 RNase is aberrantly distributed in psoriatic epidermis and rapidly induced by IL-17A.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca